Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.50 |
| ▸ | THRA | P10827 | 18/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25983465 | 0.82 | THRB (0.53) | THRBTHRA | |
| SCHEMBL328377 | 0.81 | THRB (0.67) | THRBTHRA | |
| SCHEMBL21120061 | 0.80 | THRB (0.73) | THRBTHRA | |
| SCHEMBL282437 | 0.78 | THRB (0.50) | THRBTHRA | |
| SCHEMBL282527 | 0.78 | THRB (0.63) | THRBTHRA | |
| SCHEMBL282445 | 0.76 | THRB (0.49) | THRBTHRA | |
| SCHEMBL8498068 | 0.76 | THRB (0.52) | THRBTHRA | |
| SCHEMBL282232 | 0.75 | THRB (0.48) | THRBTHRA | |
| SCHEMBL29542258 | 0.75 | THRB (0.51) | THRBTHRALMNA | |
| SCHEMBL281842 | 0.75 | THRB (0.51) | THRBTHRALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428516-A1 | Novel phosphorus-containing thyromimetics | Metabasis Therapeutics, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |