Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 9/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.40 |
| ▸ | PAK4 | O96013 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 5/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3288306 | 0.87 | PLK4 (0.40) | PLK4NTRK1PAK4RETAURKA | |
| SCHEMBL3045180 | 0.84 | RET (0.49) | PLK4NTRK1RETAURKAAURKB | |
| SCHEMBL5262600 | 0.76 | GSK3A (0.41) | PLK4NTRK1PAK4RETAURKA | |
| SCHEMBL13221325 | 0.74 | GSK3B (0.54) | AURKAAURKB | |
| SCHEMBL3041422 | 0.73 | KDM4E (0.48) | NTRK1AURKAAURKB | |
| SCHEMBL15651438 | 0.72 | FGFR4 (0.36) | PLK4PAK4AURKAAURKB | |
| SCHEMBL3041030 | 0.72 | GSK3A (0.33) | NTRK1RETAURKAAURKB | |
| SCHEMBL3288291 | 0.72 | MAP4K2 (0.41) | PLK4PAK4RETAURKAAURKB | |
| SCHEMBL3033835 | 0.72 | RET (0.47) | PLK4NTRK1RETAURKAAURKB | |
| SCHEMBL3038694 | 0.72 | GSK3B (0.39) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713973-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-11 | — | — | US | disclosed |