Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.41 |
| ▸ | SYK | P43405 | 5/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3028149 | 0.89 | MAP4K2 (0.41) | MAP4K2SYKAURKBRETMAP4K4 | |
| SCHEMBL3285891 | 0.86 | PAK1 (0.43) | IGF1R | |
| SCHEMBL3045113 | 0.86 | KARS1 (0.45) | MAP4K2SYKAURKBRETMAP4K4 | |
| SCHEMBL3031930 | 0.85 | MAP4K4 (0.41) | MAP4K2SYKAURKBRETMAP4K4 | |
| SCHEMBL3288306 | 0.85 | PLK4 (0.40) | MAP4K2AURKBRETAURKAPLK4 | |
| SCHEMBL13221395 | 0.84 | MAP4K2 (0.41) | MAP4K2SYKAURKBRETMAP4K4 | |
| SCHEMBL3038530 | 0.83 | MAP4K2 (0.38) | MAP4K2SYKAURKBRETMAP4K4 | |
| SCHEMBL3039707 | 0.83 | RET (0.49) | MAP4K2SYKAURKBRETMAP4K4 | |
| SCHEMBL13221083 | 0.83 | GSK3B (0.53) | MAP4K2SYKAURKBRETMAP4K4 | |
| SCHEMBL3046795 | 0.83 | RET (0.45) | MAP4K2SYKAURKBRETMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713973-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-11 | — | — | US | disclosed |