Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CALCRLCHRM1CHRM2CHRM3F2RMAOAMAOBMAP2K1MAP2K2NTRK1NTRK2NTRK3OPRD1OPRK1OPRM1P2RY12PKLRSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASLC18A2SLC6A2SLC6A3TLR7TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8dacAdacBdacCfolAftsImrcAmrcBmrdApolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmB1rpmB2rpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsR1rpsR2rpsSrpsTrpsUrpsZykgMykgO
The experimentally established mechanism targets of Dodecanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dodecanol SCHEMBL27573175 | 1.00 | LMNA (0.56) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| Undecanol SCHEMBL28530190 | 0.91 | LMNA (0.68) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| 1-Heptanol SCHEMBL28521538 | 0.91 | LMNA (0.68) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| 1-Heptanol SCHEMBL28521540 | 0.91 | LMNA (0.68) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| Cetostearyl Alcohol SCHEMBL7532346 | 0.91 | LMNA (0.68) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| Cetyl Alcohol SCHEMBL7531171 | 0.91 | LMNA (0.68) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| Decanol SCHEMBL11142450 | 0.91 | LMNA (0.68) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| Cetyl Alcohol SCHEMBL7531165 | 0.91 | LMNA (0.68) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| Octanol SCHEMBL8988140 | 0.91 | LMNA (0.68) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| Decanol SCHEMBL5665448 | 0.91 | LMNA (0.68) | LMNAALDH1A1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709422-B2 | Method and composition for injection at a tunnel boring machine | CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) | 2010-05-04 | — | — | US | claimed |
| CN-1308570-C | Tunnel boring method and aqueous foam used therein | MBT HOLDIGN AG (DE) | 2007-04-04 | — | — | CN | claimed |
| US-20070015667-A1 | Method and composition for injection at a tunnel boring machine | CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) | 2007-01-18 | — | — | US | claimed |
| US-6802673-B1 | Tunnel boring with foamed composition | MBT HOLDING AG (CH) | 2004-10-12 | — | — | US | claimed |
| CN-1369033-A | tunnel drilling method | MBT HOLDIGN AG (CH) | 2002-09-11 | — | — | CN | claimed |
| US-7709422-B2 | Method and composition for injection at a tunnel boring machine | CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) | 2010-05-04 | — | — | US | disclosed |
| CN-100560938-C | Be used for the method and composition injected at the tunnel borer place | CONSTR RES & TECH GMBH (DE) | 2009-11-18 | — | — | CN | disclosed |
| EP-1599654-B1 | METHOD AND COMPOSITION FOR INJECTION AT A TUNNEL BORING MACHINE | CONSTR RES & TECH GMBH (DE) | 2008-06-25 | — | — | EP | disclosed |
| CN-1308570-C | Tunnel boring method and aqueous foam used therein | MBT HOLDIGN AG (DE) | 2007-04-04 | — | — | CN | disclosed |
| US-20070015667-A1 | Method and composition for injection at a tunnel boring machine | CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) | 2007-01-18 | — | — | US | disclosed |
| CN-1756894-A | Method and composition for injection at a tunnel boring machine | CONSTR RES & TECH GMBH (DE) | 2006-04-05 | — | — | CN | disclosed |
| EP-1599654-A1 | METHOD AND COMPOSITION FOR INJECTION AT A TUNNEL BORING MACHINE | Construction Research & Technology GmbH (DE) | 2005-11-30 | — | — | EP | disclosed |
| EP-1210504-B1 | TUNNEL BORING METHOD | CONSTR RES & TECH GMBH (DE) | 2005-04-13 | — | — | EP | disclosed |
| US-6802673-B1 | Tunnel boring with foamed composition | MBT HOLDING AG (CH) | 2004-10-12 | — | — | US | disclosed |
| WO-2004076817-A1 | METHOD AND COMPOSITION FOR INJECTION AT A TUNNEL BORING MACHINE | CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) | 2004-09-10 | — | — | WO | disclosed |
| CN-1369033-A | tunnel drilling method | MBT HOLDIGN AG (CH) | 2002-09-11 | — | — | CN | disclosed |
| EP-1210504-A1 | TUNNEL BORING METHOD | MBT HOLDING AG (CH) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001012952-A1 | TUNNEL BORING METHOD | MBT HOLDING AG (CH) | 2001-02-22 | — | — | WO | disclosed |