Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13912445 | 0.89 | TDP1 (0.56) | TDP1HPGDALDH1A1CYP3A4TSHR | |
| SCHEMBL69234 | 0.88 | TDP1 (0.76) | TDP1HPGDAKR1B1PARP1CYP2C9 | |
| SCHEMBL29564952 | 0.88 | TDP1 (0.76) | TDP1HPGDAKR1B1PARP1CYP2C9 | |
| Hydrochloric Acid SCHEMBL9083734 | 0.87 | TDP1 (0.55) | TDP1HPGDALDH1A1HSD17B10AKR1B1 | |
| SCHEMBL21585563 | 0.82 | TDP1 (0.68) | TDP1HPGDAKR1B1CYP2C9CYP2C19 | |
| SCHEMBL34471877 | 0.81 | PARP1 (0.58) | TDP1HPGDALDH1A1CYP3A4TSHR | |
| SCHEMBL28012850 | 0.81 | TDP1 (0.53) | TDP1HPGDALDH1A1AKR1B1PARP1 | |
| SCHEMBL1000848 | 0.80 | PTGS2 (0.53) | TDP1HPGDAKR1B1CYP2C9CYP2C19 | |
| SCHEMBL72851 | 0.79 | AKR1B1 (0.61) | TDP1HPGDTSHRAKR1B1CYP2C9 | |
| Malonic Acid SCHEMBL28193925 | 0.79 | ALDH1A1 (0.59) | TDP1HPGDALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700595-B2 | such as 3-benzyl-4-phenyl-8-(trifluoromethyl)cinnoline; modulators of Liver X receptors (LXRs) | WYETH LLC (US) | 2010-04-20 | — | — | US | disclosed |
| US-20090069373-A1 | Quinoline Acids | WYETH (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090069373-A1 | Quinoline Acids | WYETH (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090069373-A1 | Quinoline Acids | WYETH (US) | 2009-03-12 | — | — | US | disclosed |
| CN-101166730-A | Cinnoline compounds and their use as liver X receptor modilators | WYETH CORP (US) | 2008-04-23 | — | — | CN | disclosed |
| EP-1853566-A1 | CINNOLINE COMPOUNDS AND THEIR USE AS LIVER X RECEPTOR MODULATORS | Wyeth (US) | 2007-11-14 | — | — | EP | disclosed |
| US-20060252757-A1 | Cinnoline compounds | WYETH | 2006-11-09 | — | — | US | disclosed |
| WO-2006094034-A1 | CINNOLINE COMPOUNDS AND THEIR USE AS LIVER X RECEPTOR MODILATORS | WYETH (US) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252757-A1 | Cinnoline compounds | NR1H3, NR1H2, CNR1 | TDP1 4009/4885HPGD 1370/4885ALDH1A1 938/4885 |
| US-20090069373-A1 | Quinoline Acids | NR1H3, NR1H2, NR1H4 | TDP1 4345/4885HPGD 978/4885ALDH1A1 1667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.