Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8352639 | 0.86 | CYP1A2 (1.00) | CYP1A2CYP3A4NPSR1ALDH1A1MAPK1 | |
| SCHEMBL5513393 | 0.86 | ALDH1A1 (0.63) | CYP1A2CYP3A4NPSR1ALDH1A1MAPK1 | |
| SCHEMBL30630152 | 0.84 | ALDH1A1 (0.61) | CYP1A2CYP3A4NPSR1ALDH1A1MAPK1 | |
| SCHEMBL1411774 | 0.83 | CYP1A2 (0.76) | CYP1A2CYP3A4NPSR1ALDH1A1MAPK1 | |
| SCHEMBL7127347 | 0.81 | ALDH1A1 (0.58) | CYP1A2CYP3A4NPSR1ALDH1A1MAPK1 | |
| Butane SCHEMBL10872914 | 0.79 | ALDH1A1 (0.66) | CYP1A2CYP3A4NPSR1ALDH1A1MAPK1 | |
| SCHEMBL13983006 | 0.77 | ALDH1A1 (0.63) | CYP1A2CYP3A4NPSR1ALDH1A1MAPK1 | |
| SCHEMBL15197087 | 0.77 | CYP1A2 (0.61) | CYP1A2CYP3A4NPSR1ALDH1A1MAPK1 | |
| SCHEMBL10138096 | 0.77 | CYP1A2 (0.67) | CYP1A2CYP3A4NPSR1ALDH1A1MAPK1 | |
| SCHEMBL11584471 | 0.77 | ALDH1A1 (0.52) | CYP1A2CYP3A4NPSR1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| CN-101001860-A | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (CH) | 2007-07-18 | — | — | CN | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| EP-3157938-B1 | HETERO FUNCTIONAL BINDING SYSTEMS | ANTEO TECH PTY LTD (AU) | 2022-03-16 | — | — | EP | disclosed |
| US-10768176-B2 | Hetero functional binding systems | ANTEO TECHNOLOGIES PTY LTD (AU) | 2020-09-08 | — | — | US | disclosed |
| US-20170115285-A1 | HETERO FUNCTIONAL BINDING SYSTEMS | ANTEO TECHNOLOGIES PTY LTD (AU) | 2017-04-27 | — | — | US | disclosed |
| EP-3157938-A1 | HETERO FUNCTIONAL BINDING SYSTEMS | Anteo Technologies Pty Ltd. (AU) | 2017-04-26 | — | — | EP | disclosed |
| WO-2015192183-A1 | HETERO FUNCTIONAL BINDING SYSTEMS | ANTEO TECHNOLOGIES PTY LTD (AU) | 2015-12-23 | — | — | WO | disclosed |
| US-7714018-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2010-05-11 | — | — | US | disclosed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |
| CN-101001860-A | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (CH) | 2007-07-18 | — | — | CN | disclosed |
| US-20070117859-A1 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC | 2007-05-24 | — | — | US | disclosed |
| US-7164019-B2 | Such as cyclopentanecarboxylic acid {(S)-1-phenyl-3-[5-(pyridine-3-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-propyl}-amide; antagonists of chemokine receptors, useful for treating/preventing human immunodeficiency virus infection, AIDS or ARC | ROCHE PALO ALTO LLC (US) | 2007-01-16 | — | — | US | disclosed |
| US-20060014767-A1 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014767-A1 | Heterocyclic antiviral compounds | CCR5, ACKR3, CXCR1 | CYP1A2 2047/4885CYP3A4 1730/4885NPSR1 251/4885 |
| US-20070117859-A1 | Heterocyclic antiviral compounds | CCR5, ACKR3, CXCR1 | CYP1A2 2047/4885CYP3A4 1730/4885NPSR1 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.