Oxaprozin

Oxaprozin

SCHEMBL3286

O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PTGS1PTGS2

The experimentally established mechanism targets of Oxaprozin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 known ✓ P23219 1/20 1.00
PTGS2 known ✓ P35354 1/20 1.00
RXRA P19793 19/20 1.00
RXRB P28702 19/20 1.00
RXRG P48443 15/20 1.00
NR4A2 P43354 7/20 1.00
KDM4E B2RXH2 1/20 1.00
ABCC4 O15439 1/20 1.00
C5 P01031 1/20 1.00
LMNA P02545 1/20 1.00
CHRM2 P08172 1/20 1.00
CYP3A4 P08684 1/20 1.00
CHRM1 P11229 1/20 1.00
DRD2 P14416 1/20 1.00
HPGD P15428 1/20 1.00
TSHR P16473 1/20 1.00
TBXA2R P21731 1/20 1.00
NR4A1 P22736 1/20 1.00
HTR2A P28223 1/20 1.00
HTR2C P28335 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxaprozin SCHEMBL8191237 1.00 RXRA (1.00) RXRARXRBRXRGNR4A2KDM4E
Oxaprozin SCHEMBL3849972 1.00 RXRA (1.00) RXRARXRBRXRGNR4A2KDM4E
Oxaprozin SCHEMBL8191554 0.98 RXRA (0.97) RXRARXRBRXRGNR4A2KDM4E
Oxaprozin SCHEMBL8190680 0.98 RXRA (0.97) RXRARXRBRXRGNR4A2KDM4E
Oxaprozin SCHEMBL5732754 0.98 RXRA (0.97) RXRARXRBRXRGNR4A2KDM4E
Oxaprozin SCHEMBL137988 0.98 RXRA (0.97) RXRARXRBRXRGNR4A2KDM4E
Oxaprozin SCHEMBL6380181 0.98 RXRA (0.97) RXRARXRBRXRGNR4A2KDM4E
Oxaprozin SCHEMBL28469762 0.98 RXRA (0.97) RXRARXRBRXRGNR4A2KDM4E
Oxaprozin SCHEMBL10968776 0.97 RXRA (0.94) RXRARXRBRXRGNR4A2KDM4E
Oxaprozin SCHEMBL8607424 0.96 RXRA (0.91) RXRARXRBRXRGNR4A2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 54490 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122094963-A Cardioprotective lipids and methods of use 2026-05-26 CN claimed
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 US claimed
WO-2026106917-A1 EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL BioPhysics Pharma, Inc. (US) 2026-05-21 WO claimed
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
US-20260132191-A1 METHODS FOR MODULATING ACTIVITY OF IL-18 FOR TREATMENT OF CD4+ T CELL MEDIATED AUTOIMMUNITY AND IMMUNOPATHOLOGY THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) 2026-05-14 US claimed
US-20260130928-A1 COMBINATION OF AKR1C3 ACTIVATED ANTICANCER PRODRUG COMPOUND AND ANALGESIC DRUG FOR TREATING CANCER PATIENTS ACCOMPANIED BY PAIN ASCENTAWITS PHARMACEUTICALS LTD (CN) 2026-05-14 US claimed
EP-3917993-B1 MULTI-COAT POLYMER PHOTONIC CRYSTAL FILMS UNIV COLORADO STATE RES FOUND (US) 2026-05-13 EP claimed
CN-122028914-A Combination therapy for autoimmune disorders 拜奥海芬治疗学有限公司 2026-05-12 CN claimed
CN-122004216-A Herbicide composition containing cyclohexene diketone lactic acid oxime ether derivative and application thereof 郑州手性药物研究院有限公司 2026-05-12 CN claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
WO-1985004589-A1 COUGH/COLD MIXTURES COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS SUNSHINE ABRAHAM 1985-10-24 WO claimed
EP-0063884-B1 OXAZOLE DERIVATIVES, THEIR PREPARATION AND USE JOHN WYETH & BROTHER LIMITED (GB) 1985-06-26 EP claimed
WO-1985002542-A1 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME SUNSHINE ABRAHAM 1985-06-20 WO claimed
US-4522826-A SYNERGISTIC MIXTURES RICHARDSON-VICKS INC. (US) 1985-06-11 US claimed
US-4486436-A Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same ANALGESIC ASSOCIATES (US) 1984-12-04 US claimed
EP-0114886-A1 IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE. SUNSHINE ABRAHAM (US) 1984-08-08 EP claimed
WO-1984002273-A1 ANALGESIC COMBINATIONS SANDOZ AG (CH) 1984-06-21 WO claimed
EP-0111456-A1 Analgesic combinations Cooper, Stephen A. Dr. (US) 1984-06-20 EP claimed
WO-1984000490-A1 IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME SUNSHINE ABRAHAM 1984-02-16 WO claimed
EP-0063884-A1 Oxazole derivatives, their preparation and use JOHN WYETH & BROTHER LIMITED (GB) 1982-11-03 EP claimed