Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxaprozin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 1.00 |
| ▸ | RXRA | P19793 | 19/20 | 1.00 |
| ▸ | RXRB | P28702 | 19/20 | 1.00 |
| ▸ | RXRG | P48443 | 15/20 | 1.00 |
| ▸ | NR4A2 | P43354 | 7/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | C5 | P01031 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | NR4A1 | P22736 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxaprozin SCHEMBL3286 | 1.00 | RXRA (1.00) | RXRARXRBRXRGNR4A2KDM4E | |
| Oxaprozin SCHEMBL8191237 | 1.00 | RXRA (1.00) | RXRARXRBRXRGNR4A2KDM4E | |
| Oxaprozin SCHEMBL8191554 | 0.98 | RXRA (0.97) | RXRARXRBRXRGNR4A2KDM4E | |
| Oxaprozin SCHEMBL8190680 | 0.98 | RXRA (0.97) | RXRARXRBRXRGNR4A2KDM4E | |
| Oxaprozin SCHEMBL5732754 | 0.98 | RXRA (0.97) | RXRARXRBRXRGNR4A2KDM4E | |
| Oxaprozin SCHEMBL137988 | 0.98 | RXRA (0.97) | RXRARXRBRXRGNR4A2KDM4E | |
| Oxaprozin SCHEMBL6380181 | 0.98 | RXRA (0.97) | RXRARXRBRXRGNR4A2KDM4E | |
| Oxaprozin SCHEMBL28469762 | 0.98 | RXRA (0.97) | RXRARXRBRXRGNR4A2KDM4E | |
| Oxaprozin SCHEMBL10968776 | 0.97 | RXRA (0.94) | RXRARXRBRXRGNR4A2KDM4E | |
| Oxaprozin SCHEMBL8607424 | 0.96 | RXRA (0.91) | RXRARXRBRXRGNR4A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054052-A1 | DRUG COMBINATION PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USING THEM | Vicus Therapeutics SPE 1, LLC (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008014471-A1 | DRUG COMBINATION PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USING THEM | VICUS THERAPEUTICS SPE 1, LLC (US) | 2008-01-31 | — | — | WO | disclosed |
| WO-2006083508-A2 | COMBINATIONS OF SUPEROXIDE DISMUTASE MIMETICS AND NONSTEROIDAL ANALGESIC/ANTI-INFLAMMATORY DRUGS | METAPHORE PHARMACEUTICALS INC. (US) | 2006-08-10 | — | — | WO | disclosed |
| US-6030643-A | Potassium, sodium and tris oxaprozin salt pharmaceutical formulations | G.D. SEARLE & CO. (US) | 2000-02-29 | — | — | US | disclosed |
| EP-0901372-A1 | POTASSIUM, SODIUM AND TRIS OXAPROZIN SALT PHARMACEUTICAL FORMULATIONS | G.D. SEARLE & CO. (US) | 1999-03-17 | — | — | EP | disclosed |
| EP-0805684-A4 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | UNIV TEXAS (US) | 1998-08-05 | — | — | EP | disclosed |
| WO-1998013073-A1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDs AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-04-02 | — | — | WO | disclosed |
| WO-1997044022-A1 | POTASSIUM, SODIUM AND TRIS OXAPROZIN SALT PHARMACEUTICAL FORMULATIONS | G.D. SEARLE & CO. (US) | 1997-11-27 | — | — | WO | disclosed |
| EP-0805684-A2 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022780-A1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 1996-08-01 | — | — | WO | disclosed |