Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.72 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.72 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5144572 | 0.85 | HRH4 (0.58) | HRH4HRH3 | |
| SCHEMBL30488018 | 0.84 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL2169898 | 0.84 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL10849481 | 0.82 | HRH4 (0.90) | HRH4HRH3 | |
| SCHEMBL22275729 | 0.81 | HRH4 (0.59) | HRH4HRH3HTR3A | |
| SCHEMBL30068075 | 0.81 | HRH4 (0.49) | HRH4HRH3 | |
| SCHEMBL26647349 | 0.81 | HRH4 (0.49) | HRH4HRH3 | |
| SCHEMBL793547 | 0.81 | HRH4 (0.51) | HRH4HRH3 | |
| SCHEMBL30011158 | 0.81 | HRH4 (0.51) | HRH4HRH3 | |
| SCHEMBL794010 | 0.81 | CRHBP (0.61) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101796046-A | Pyrimidine derivatives 934 | ASTRAZENECA AB | 2010-08-04 | — | — | CN | disclosed |
| US-7718653-B2 | Pyrimidine derivatives for inhibiting Eph receptors | ASTRAZENECA AB (SE) | 2010-05-18 | — | — | US | disclosed |
| EP-2183242-A2 | PYRIMIDINE DERIVATIVES 934 | AstraZeneca AB (SE) | 2010-05-12 | — | — | EP | disclosed |
| US-20090023719-A1 | PYRIMIDINE DERIVATIVES 934 | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | US | disclosed |
| WO-2009010789-A2 | PYRIMIDINE DERIVATIVES 934 | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023719-A1 | PYRIMIDINE DERIVATIVES 934 | EPHB4, EPHA2, EPHB1 | HRH4 177/4885HRH3 363/4885HTR3A 980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.