Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3286587 | 0.85 | HRH4 (0.72) | HRH4HRH3 | |
| SCHEMBL794010 | 0.84 | CRHBP (0.61) | HRH4SMN1; SMN2CRHBPCRHR2KMT2A | |
| SCHEMBL30068075 | 0.81 | HRH4 (0.49) | HRH4SMN1; SMN2CRHBPCRHR2KMT2A | |
| SCHEMBL26647349 | 0.81 | HRH4 (0.49) | HRH4SMN1; SMN2CRHBPCRHR2KMT2A | |
| SCHEMBL28957811 | 0.81 | HRH4 (0.58) | HRH4SMN1; SMN2CRHBPCRHR2KMT2A | |
| SCHEMBL10678810 | 0.80 | HRH4 (0.70) | HRH4SMN1; SMN2CRHBPCRHR2HRH3 | |
| SCHEMBL30296862 | 0.80 | HRH4 (0.70) | HRH4SMN1; SMN2CRHBPCRHR2HRH3 | |
| SCHEMBL5790244 | 0.80 | SMN1; SMN2 (0.65) | HRH4SMN1; SMN2CRHBPCRHR2KMT2A | |
| SCHEMBL31503138 | 0.78 | HRH4 (0.68) | HRH4SMN1; SMN2CRHBPCRHR2KMT2A | |
| SCHEMBL5791348 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2CRHBPCRHR2KMT2ANUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2008210-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007105023-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2007-09-20 | — | — | WO | disclosed |