Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alendronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 18/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alendronic Acid SCHEMBL3110183 | 0.98 | FDPS (0.96) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL3388 | 0.98 | FDPS (0.96) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL5973704 | 0.98 | FDPS (0.96) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL204535 | 0.98 | FDPS (0.96) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL536412 | 0.98 | FDPS (0.96) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL5984073 | 0.98 | FDPS (0.96) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL14840776 | 0.96 | FDPS (0.93) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL177947 | 0.96 | FDPS (0.93) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL2282827 | 0.96 | FDPS (0.93) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL7744621 | 0.96 | FDPS (0.92) | FDPSPDE3ALMNAADRB3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2978 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250170274-A1 | GENE THERAPEUTICS FOR TREATING BONE DISORDERS | UNIVERSITY OF MASSACHUSETTS (US) | 2025-05-29 | — | — | US | claimed |
| CN-119143096-A | Calcium carbonate/calcium phosphate composite hollow nanosphere and preparation method and application thereof | 西安交通大学 | 2024-12-17 | — | — | CN | claimed |
| US-20240336654-A1 | ANTIMICROBIAL PEPTIDOMIMETICS | Universität Zürich (CH) | 2024-10-10 | — | — | US | claimed |
| EP-4380689-A1 | ANTIMICROBIAL PEPTIDOMIMETICS | Basilea Pharmaceutica International AG, Allschwil (CH) | 2024-06-12 | — | — | EP | claimed |
| CN-118043339-A | Antimicrobial peptidomimetics | 巴斯利尔药物阿尔施维尔国际股份公司 | 2024-05-14 | — | — | CN | claimed |
| EP-3439667-B1 | CGAS ANTAGONIST COMPOUNDS | IMMUNE SENSOR LLC (US) | 2024-01-03 | — | — | EP | claimed |
| EP-4169576-A1 | GENE THERAPEUTICS FOR TREATING BONE DISORDERS | University of Massachusetts (US) | 2023-04-26 | — | — | EP | claimed |
| WO-2023012319-A1 | ANTIMICROBIAL PEPTIDOMIMETICS | SPEXIS AG (CH) | 2023-02-09 | — | — | WO | claimed |
| EP-3244911-A1 | ANTIBODIES, COMPOUNDS AND DERIVATIVES THEREOF FOR USE IN THE TREATMENT OF MALE INFERTILITY | Rigshospitalet, Copenhagen University Hospital (DK) | 2017-11-22 | — | — | EP | claimed |
| WO-2016112916-A1 | ANTIBODIES, COMPOUNDS AND DERIVATIVES THEREOF FOR USE IN THE TREATMENT OF MALE INFERTILITY | RIGSHOSPITALET COPENHAGEN UNIVERSITY HOSPITAL (DK) | 2016-07-21 | — | — | WO | claimed |
| EP-0462663-B1 | Improved process for preparing salts of 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid (ABP) | MERCK & CO INC (US) | 1995-09-27 | — | — | EP | claimed |
| US-5358941-A | Treatment of bone disorders, osteoporosis | MERCK & CO., INC. (US) | 1994-10-25 | — | — | US | claimed |
| EP-0617624-A1 | TREATMENT OF PERIODONTAL DISEASE WITH ALENDRONATE. | MERCK & CO INC (US) | 1994-10-05 | — | — | EP | claimed |
| WO-1994012200-A1 | DRY MIX FORMULATION FOR BISPHOSPHONIC ACIDS | MERCK & CO., INC. (US) | 1994-06-09 | — | — | WO | claimed |
| US-5270365-A | Prevention and treatment of periodontal disease with alendronate | MERCK & CO., INC. (US) | 1993-12-14 | — | — | US | claimed |
| WO-1993011774-A1 | TREATMENT OF PERIODONTAL DISEASE WITH ALENDRONATE | MERCK & CO., INC. (US) | 1993-06-24 | — | — | WO | claimed |
| EP-0462663-A1 | Improved process for preparing salts of 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid (ABP) | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | claimed |
| US-5019651-A | Reacting 4-Aminobutyric Acid With Phosphorous Acid And Phosphorus Chloride | MERCK & CO., INC. (US) | 1991-05-28 | — | — | US | claimed |
| EP-0402152-A2 | Crystalline 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid monosodium trihydrate, process therefor and compositions and use thereof | MERCK & CO. INC. (US) | 1990-12-12 | — | — | EP | claimed |
| US-4922007-A | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof | MERCK & CO., INC. (US) | 1990-05-01 | — | — | US | claimed |