Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alendronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 18/20 | 0.96 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alendronic Acid SCHEMBL5973704 | 1.00 | FDPS (0.96) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL536412 | 1.00 | FDPS (0.96) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL204535 | 1.00 | FDPS (0.96) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL5984073 | 1.00 | FDPS (0.96) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL3110183 | 1.00 | FDPS (0.96) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL14840776 | 0.98 | FDPS (0.93) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL177947 | 0.98 | FDPS (0.93) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL2282827 | 0.98 | FDPS (0.93) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL328770 | 0.98 | FDPS (1.00) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL7749180 | 0.96 | FDPS (0.89) | FDPSPDE3ALMNAADRB3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 15651 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122005663-A | Application of aconite in treating kidney-yang deficiency type osteoporosis | 重庆医科大学 | 2026-05-12 | — | — | CN | claimed |
| CN-122005953-A | Drug mineralized gel and preparation method and application thereof | 中国科学院兰州化学物理研究所 | 2026-05-12 | — | — | CN | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| CN-121570641-A | Hydrogel for repairing osteoporosis bone defect and preparation method thereof | 西南交通大学 | 2026-02-27 | — | — | CN | claimed |
| EP-3787631-B1 | MODULATORS OF ORPHAN NUCLEAR RECEPTORS FOR NASH AND OTHER METABOLIC DISORDERS | UNIV EMORY (US) | 2025-09-10 | — | — | EP | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-12337065-B2 | Compositions for treating viral infections and methods for same | ACCESS TO ADVANCED HEALTH INSTITUTE (US) | 2025-06-24 | — | — | US | claimed |
| CN-120154943-A | Hemodialysis adsorbent, preparation method, hemodialysis adsorption column and blood purification device | 上海天佑医院有限公司 | 2025-06-17 | — | — | CN | claimed |
| CN-119656381-B | Active organic-inorganic composite implant material and preparation method and application thereof | 广东粤港澳大湾区黄埔材料研究院 | 2025-06-13 | — | — | CN | claimed |
| CN-120022763-A | Long-acting reverse osmosis RO membrane filter material and preparation method thereof | 四川耐氏环保科技有限公司 | 2025-05-23 | — | — | CN | claimed |
| US-5773429-A | Drug combination for treating calcium loss | FUISZ TECHNOLOGIES LTD. (US) | 1998-06-30 | — | — | US | claimed |
| WO-1998025628-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING ALENDRONATE AND AN AGENT PROMOTING GASTRIC EMPTYING | FUISZ TECHNOLOGIES LTD. (US) | 1998-06-18 | — | — | WO | claimed |
| CN-1181008-A | Method of lessening the risk of vertebral fractures | MARCK & CO INC (US) | 1998-05-06 | — | — | CN | claimed |
| CN-1181012-A | Method of lessening the rish of non-vertebral bone fractures | MARCK & CO INC (US) | 1998-05-06 | — | — | CN | claimed |
| WO-1998014196-A1 | LIQUID ALENDRONATE FORMULATIONS | MERCK & CO., INC. (US) | 1998-04-09 | — | — | WO | claimed |
| EP-0824341-A1 | PREVENTION OF TOOTH LOSS BY THE ADMINISTRATION OF ALENDRONATE OR ITS SALTS | Merck & Co., Inc. (US) | 1998-02-25 | — | — | EP | claimed |
| WO-1997044017-A1 | EFFERVESCENT BISPHOSPHONATE FORMULATION | MERCK & CO., INC. (US) | 1997-11-27 | — | — | WO | claimed |
| WO-1997029754-A1 | TOPICAL BISPHOSPHONATES FOR PREVENTION OF BONE RESORPTION | BINDERMAN ITZHAK (IL) | 1997-08-21 | — | — | WO | claimed |
| US-5646134-A | INHIBITING BONE RESORPTION | MERCK & CO., INC. (US) | 1997-07-08 | — | — | US | claimed |
| WO-1996035407-A1 | PREVENTION OF TOOTH LOSS BY THE ADMINISTRATION OF ALENDRONATE OR ITS SALTS | MERCK & CO., INC. (US) | 1996-11-14 | — | — | WO | claimed |