Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 0.72 |
| ▸ | HSD11B2 | P80365 | 8/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328786 | 1.00 | HSD11B1 (0.72) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL328764 | 0.84 | HSD11B1 (1.00) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL328766 | 0.84 | HSD11B1 (1.00) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4770323 | 0.84 | HSD11B1 (1.00) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2821799 | 0.77 | HSD11B1 (0.78) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2821801 | 0.77 | HSD11B1 (0.78) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL328870 | 0.75 | HSD11B1 (0.86) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL328850 | 0.74 | HSD11B1 (1.00) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL328765 | 0.70 | HSD11B1 (0.83) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2823094 | 0.70 | HSD11B1 (0.68) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2407452-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme | Abbott Laboratories (US) | 2012-01-18 | — | — | EP | disclosed |