SCHEMBL4770323

CC1(C)C(=O)N(C2C3CC4CC2CC(/C(N)=N/O)(C4)C3)CC1COc1ccc(C(F)(F)F)cn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	HSD11B1	P28845	20/20	1.00

▸	HSD11B2	P80365	9/20	1.00

▸	CYP3A4	P08684	2/20	0.38

▸	CYP2D6	P10635	2/20	0.38

▸	CYP2C9	P11712	2/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL328766	1.00	HSD11B1 (1.00)	HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9
SCHEMBL328764	1.00	HSD11B1 (1.00)	HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9
SCHEMBL328870	0.91	HSD11B1 (0.86)	HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9
SCHEMBL328850	0.91	HSD11B1 (1.00)	HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9
SCHEMBL2821801	0.88	HSD11B1 (0.78)	HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9
SCHEMBL2821799	0.88	HSD11B1 (0.78)	HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9
SCHEMBL328765	0.86	HSD11B1 (0.83)	HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9
SCHEMBL328785	0.84	HSD11B1 (0.72)	HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9
SCHEMBL328786	0.84	HSD11B1 (0.72)	HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9
SCHEMBL361466	0.83	HSD11B1 (0.73)	HSD11B1HSD11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2007719-A2	INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME	Abbott Laboratories (US)	2008-12-31	—	—	EP	disclosed
WO-2007118185-A2	INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME	ABBOTT LABORATORIES (US)	2007-10-18	—	—	WO	disclosed