Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.45 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.44 |
| ▸ | PI4KA | P42356 | 2/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | AHCY | P23526 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913580 | 0.86 | CYP3A4 (0.50) | CYP3A4ADORA2AADORA1FGFR1SLC22A6 | |
| SCHEMBL2912070 | 0.85 | CYP3A4 (0.49) | CYP3A4ADORA2AADORA1FGFR1SLC22A6 | |
| SCHEMBL3134817 | 0.82 | HSP90AB1 (0.41) | — | |
| SCHEMBL5016005 | 0.82 | ADORA2A (0.47) | CYP3A4ADORA2AADORA1METTL3METTL14 | |
| SCHEMBL3293432 | 0.82 | FGFR1 (0.47) | CYP3A4ADORA2AADORA1FGFR1SLC22A6 | |
| SCHEMBL2937354 | 0.81 | FAP (0.52) | CYP3A4ADORA2AADORA1FGFR1SLC22A6 | |
| SCHEMBL2904496 | 0.81 | FGFR1 (0.61) | CYP3A4ADORA2AADORA1FGFR1SLC22A6 | |
| SCHEMBL13328610 | 0.78 | CYP3A4 (0.50) | CYP3A4ADORA2AADORA1FGFR1SLC22A6 | |
| SCHEMBL2913613 | 0.76 | CYP3A4 (0.48) | CYP3A4ADORA2AADORA1FGFR1SLC22A6 | |
| SCHEMBL9189753 | 0.76 | CYP3A4 (0.57) | CYP3A4ADORA2AADORA1FGFR1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723319-B2 | Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | LG LIFE SCIENCES LTD. (KR) | 2010-05-25 | — | — | US | disclosed |
| US-7157448-B2 | Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | LG LIFE SCIENCES LTD. (KR) | 2007-01-02 | — | — | US | disclosed |
| US-20060052346-A1 | Nucleoside phosphonate derivatives useful in the treatment of HIV infections | LG LIFE SCIENCES LTD. (KR) | 2006-03-09 | — | — | US | disclosed |
| US-20040063668-A1 | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | LG LIFE SCIENCES LTD. (KR) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052346-A1 | Nucleoside phosphonate derivatives useful in the treatment of HIV infections | PNP, TYMP, ENTPD5 | CYP3A4 1213/4885ADORA2A 390/4885ADORA1 261/4885 |
| US-20040063668-A1 | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | PNP, ITPA, MTAP | CYP3A4 456/4885ADORA2A 119/4885ADORA1 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.