Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 12/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61068 | 0.98 | CYP2D6 (0.69) | CYP2D6TSHRHSD17B10MAPTALDH1A1 | |
| SCHEMBL2906835 | 0.90 | HSD17B10 (0.63) | CYP2D6TSHRHSD17B10MAPTALDH1A1 | |
| Bromide SCHEMBL8009452 | 0.86 | CYP2D6 (0.62) | CYP2D6TSHRHSD17B10MAPTALDH1A1 | |
| SCHEMBL1049070 | 0.84 | CYP2D6 (0.64) | CYP2D6TSHRHSD17B10MAPTALDH1A1 | |
| Bromide SCHEMBL11514508 | 0.83 | KDM4E (0.63) | CYP2D6TSHRHSD17B10MAPTALDH1A1 | |
| Bromide SCHEMBL10776612 | 0.82 | CYP2D6 (0.97) | CYP2D6TSHRHSD17B10MAPTALDH1A1 | |
| Bromide SCHEMBL11507050 | 0.82 | CYP2D6 (0.76) | CYP2D6TSHRHSD17B10MAPTALDH1A1 | |
| SCHEMBL12201148 | 0.82 | CYP2D6 (0.62) | CYP2D6TSHRHSD17B10MAPTALDH1A1 | |
| Iodide SCHEMBL5131519 | 0.82 | CYP2D6 (0.62) | CYP2D6TSHRHSD17B10MAPTALDH1A1 | |
| Bromide SCHEMBL1506908 | 0.81 | MAPT (0.63) | CYP2D6TSHRHSD17B10MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4347305-A | NONSILVER PHOTOGRAPHIC COATING OVER SILVER NALIDE EMULSION; POSITIVES; PHOTORESISTS; MASKING; | FUJI PHOTO FILM CO., LTD. (JP) | 1982-08-31 | — | — | US | claimed |
| US-4168167-A | ALUMINUM OXIDE FILM ON ALUMINUM, SILVER HALIDE EMULSIONS, ANTIFOGGING AGENTS | FUJI PHOTO FILM CO., LTD. (JP) | 1979-09-18 | — | — | US | claimed |
| US-7709653-B2 | Asymmetric cyanine compounds, their preparation methods and their uses | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO. LTD. (CN) | 2010-05-04 | — | — | US | disclosed |
| US-20090305285-A1 | ASYMMETRIC CYANINE COMPOUNDS, THEIR PREPARATION METHODS AND THEIR USES | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2009-12-10 | — | — | US | disclosed |
| EP-1303751-B1 | DYES AND METHODS OF DETECTION OF NUCLEIC ACID IN IMMATURE RED BLOOD CELLS | COULTER INT CORP (US) | 2005-08-10 | — | — | EP | disclosed |
| EP-1303751-A4 | DYES AND METHODS OF DETECTION OF NUCLEIC ACID IN IMMATURE RED BLOOD CELLS | COULTER INT CORP (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1303751-A1 | DYES AND METHODS OF DETECTION OF NUCLEIC ACID IN IMMATURE RED BLOOD CELLS | Coulter International Corp. (US) | 2003-04-23 | — | — | EP | disclosed |
| US-6551831-B2 | Detection of nucleic acids in red blood cells by flow cytometry by employing fluorescent, nucleic acid binidng cyanine dye | COULTER INTERNATIONAL CORP. | 2003-04-22 | — | — | US | disclosed |
| US-6368864-B1 | Dyes and methods of reticulocyte enumeration | COULTER INTERNATIONAL CORP. | 2002-04-09 | — | — | US | disclosed |
| US-20020037589-A1 | Dyes and methods of detection of nucleic acid in immature red blood cells | COULTER INTERNATIONAL CORP. | 2002-03-28 | — | — | US | disclosed |
| WO-2001086264-A1 | DYES AND METHODS OF DETECTION OF NUCLEIC ACID IN IMMATURE RED BLOOD CELLS | COULTER INTERNATIONAL CORP. (US) | 2001-11-15 | — | — | WO | disclosed |
| US-5198324-A | Multilayer printing plates | MITSUBISHI PAPER MILLS LIMITED (JP) | 1993-03-30 | — | — | US | disclosed |
| US-4347305-A | NONSILVER PHOTOGRAPHIC COATING OVER SILVER NALIDE EMULSION; POSITIVES; PHOTORESISTS; MASKING; | FUJI PHOTO FILM CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |
| US-4168167-A | ALUMINUM OXIDE FILM ON ALUMINUM, SILVER HALIDE EMULSIONS, ANTIFOGGING AGENTS | FUJI PHOTO FILM CO., LTD. (JP) | 1979-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090305285-A1 | ASYMMETRIC CYANINE COMPOUNDS, THEIR PREPARATION METHODS AND THEIR USES | IK, RCN1, RCC1 | CYP2D6 2487/4885TSHR 2864/4885HSD17B10 3787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.