Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 10/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3289482 | 1.00 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTL3MBTL1CYP3A4 | |
| SCHEMBL3294950 | 0.95 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPTL3MBTL1CYP3A4 | |
| SCHEMBL3290680 | 0.76 | MGAM (0.39) | KDM4EL3MBTL1CYP1A2BCHETDP1 | |
| SCHEMBL3292068 | 0.75 | CYP3A4 (0.43) | ALDH1A1KDM4EMAPTCYP3A4HPGD | |
| SCHEMBL3292072 | 0.75 | CYP3A4 (0.43) | ALDH1A1KDM4EMAPTCYP3A4HPGD | |
| SCHEMBL4234474 | 0.74 | BCHE (0.65) | KDM4EL3MBTL1BCHE | |
| SCHEMBL19490990 | 0.73 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTL3MBTL1CYP3A4 | |
| SCHEMBL3291010 | 0.73 | ALDH1A1 (0.63) | ALDH1A1KDM4EMAPTL3MBTL1CYP3A4 | |
| SCHEMBL3292946 | 0.72 | GAA (0.34) | ALDH1A1KDM4EGAAHPGDMEN1 | |
| SCHEMBL3292942 | 0.72 | GAA (0.34) | ALDH1A1KDM4EGAAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728155-B2 | Dihydrobenzofuranyl alkanamines and methods for using same as cns agents | WYETH LLC (US) | 2010-06-01 | — | — | US | disclosed |
| US-20050124692-A1 | Dihydrobenzofuranyl alkanamines and methods for using same as cns agents | WYETH (US) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124692-A1 | Dihydrobenzofuranyl alkanamines and methods for using same as cns agents | HTR2C, HTR1A, HTR1B | ALDH1A1 185/4885KDM4E 2343/4885MAPT 1562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.