SCHEMBL328950

SCHEMBL328950

O=C1C2CC3CC1CC(C(=O)O)(C3)C2

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 2/20 0.52
TSHR P16473 3/20 0.40
ALDH1A1 P00352 3/20 0.40
NPSR1 Q6W5P4 1/20 0.40
POLB P06746 1/20 0.40
HSD11B1 P28845 4/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
CNR2 P34972 1/20 0.36
KDM4E B2RXH2 2/20 0.36
HTT P42858 2/20 0.36
LMNA P02545 1/20 0.36
PKM P14618 1/20 0.35
P2RX7 Q99572 1/20 0.35
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1847669 1.00 EPHX2 (0.52) EPHX2TSHRALDH1A1NPSR1POLB
SCHEMBL1847665 1.00 EPHX2 (0.52) EPHX2TSHRALDH1A1NPSR1POLB
SCHEMBL23815408 1.00 EPHX2 (0.52) EPHX2TSHRALDH1A1NPSR1POLB
SCHEMBL1847663 1.00 EPHX2 (0.52) EPHX2TSHRALDH1A1NPSR1POLB
SCHEMBL1398388 0.83 EPHX2 (0.52) EPHX2TSHRALDH1A1NPSR1POLB
SCHEMBL2719341 0.82 EPHX2 (0.50) EPHX2TSHRALDH1A1NPSR1POLB
SCHEMBL6495033 0.82 EPHX2 (0.50) EPHX2TSHRALDH1A1NPSR1POLB
SCHEMBL25041744 0.82 EPHX2 (0.50) EPHX2TSHRALDH1A1NPSR1POLB
SCHEMBL19557168 0.79 HSD11B1 (0.48) EPHX2ALDH1A1HSD11B1L3MBTL1KDM4E
SCHEMBL19557166 0.79 HSD11B1 (0.48) EPHX2ALDH1A1HSD11B1L3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 378 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112876507-A Trisubstituted olefin tertiary phosphine compound and preparation method thereof 湖北大学 2021-06-01 CN claimed
CN-112250709-A Synthesis method of ortho-aryl substituted tertiary phosphine compound 湖北大学 2021-01-22 CN claimed
CN-104926672-A Method for preparing 4-amino-adamantanecarboxylic acid SHANGHAI B&C CHEMICAL CO LTD 2015-09-23 CN claimed
US-12590070-B2 Adamantane derivatives as inhibitors of focal adhesion kinase SAMJIN PHARMACEUTICAL CO., LTD. (KR) 2026-03-31 US disclosed
US-20250325660-A1 IMMUNOMODULATOR COMPOUNDS AND METHODS OF USE INCYTE CORP (US) 2025-10-23 US disclosed
CN-120136747-A Method for preparing adamantane esterified product by utilizing microchannel reactor 苏州威迈芯材半导体有限公司 2025-06-13 CN disclosed
US-20250164877-A1 RADIATION-SENSITIVE COMPOSITION, METHOD FOR FORMING RESIST PATTERN, AND RADIATION-SENSITIVE ACID GENERATOR JSR CORPORATION (JP) 2025-05-22 US disclosed
EP-4074697-B1 NOVEL ADAMANTANE DERIVATIVES AS INHIBITORS OF FOCAL ADHESION KINASE SAMJIN PHARM CO LTD (KR) 2025-05-21 EP disclosed
WO-2025070119-A1 RADIATION-SENSITIVE COMPOSITION, PATTERN FORMATION METHOD, AND ONIUM SALT COMPOUND JSR株式会社 2025-04-03 WO disclosed
WO-2025070125-A1 RADIATION-SENSITIVE COMPOSITION AND PATTERN FORMATION METHOD JSR株式会社 2025-04-03 WO disclosed
US-20250013150-A1 RADIATION-SENSITIVE COMPOSITION, PATTERN FORMATION METHOD, AND PHOTO-DEGRADABLE BASE JSR CORPORATION (JP) 2025-01-09 US disclosed
US-5543295-A ENZYMATICALLY CLEAVABLE; ANALYZING TROPIX, INC. (US) 1996-08-06 US disclosed
US-5395836-A Adenosine A1 receptor antagonists KYOWA HAKKO KOGYO CO., LTD. (JP) 1995-03-07 US disclosed
EP-0619316-A1 Xanthine derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 1994-10-12 EP disclosed
US-5330900-A Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes TROPIX, INC. (US) 1994-07-19 US disclosed
US-5326882-A High speed bioassay TROPIX, INC. (US) 1994-07-05 US disclosed
US-5220005-A Reactable with enzyme to release optically detectable energy TROPIX, INC. (US) 1993-06-15 US disclosed
EP-0497972-A1 CHEMILUMINESCENT 3-(SUBSTITUTED ADAMANT-2'-YLIDENE) 1,2-DIOXETANES TROPIX, INC. (US) 1992-08-12 EP disclosed
US-5112960-A Enzyme cleavable 1,2-dioxetane compound APPLIED BIOSYSTEMS, LLC 1992-05-12 US disclosed
WO-1992004341-A1 CHEMILUMINESCENT 3-(SUBSTITUTED ADAMANT-2'-YLIDENE) 1,2-DIOXETANES TROPIX, INC. (US) 1992-03-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250013150-A1 RADIATION-SENSITIVE COMPOSITION, PATTERN FORMATION METHOD, AND PHOTO-DEGRADABLE BASE NR2E3, RER1, H1-3 EPHX2 840/4885TSHR 136/4885ALDH1A1 1767/4885
US-20250325660-A1 IMMUNOMODULATOR COMPOUNDS AND METHODS OF USE CD274, PDCD1LG2, PDCD1 EPHX2 4129/4885TSHR 573/4885ALDH1A1 1759/4885
US-12590070-B2 Adamantane derivatives as inhibitors of focal adhesion kinase PTK2, CTTN, ADGRF1 EPHX2 1409/4885TSHR 1916/4885ALDH1A1 1097/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.