Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2566024 | 0.75 | HDAC1 (0.53) | HDAC1HDAC6HDAC8HDAC11HDAC3 | |
| SCHEMBL3318689 | 0.73 | HDAC1 (0.52) | HDAC1HDAC6HRH3HDAC8HDAC11 | |
| SCHEMBL2566848 | 0.73 | HDAC3 (0.69) | HDAC1HDAC6HDAC8HDAC11HDAC3 | |
| SCHEMBL2566578 | 0.73 | HDAC1 (0.55) | HDAC1HDAC6HDAC8HDAC11HDAC3 | |
| SCHEMBL12999350 | 0.71 | HDAC1 (0.54) | HDAC1HDAC6HDAC8HDAC11HDAC3 | |
| SCHEMBL2563898 | 0.69 | HDAC1 (0.56) | HDAC1HDAC6HPGDHDAC8HDAC11 | |
| SCHEMBL22570479 | 0.69 | USP2 (0.58) | HDAC1HDAC6ALDH1A1MAPTHDAC8 | |
| SCHEMBL28789200 | 0.67 | HDAC1 (0.63) | HDAC1HDAC6ALDH1A1HDAC8POLB | |
| SCHEMBL25246959 | 0.64 | HRH3 (0.39) | KMT2AMEN1HRH3ALDH1A1MAPT | |
| SCHEMBL26097971 | 0.64 | OPRM1 (0.49) | KMT2AMEN1HPGDHRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723376-B2 | 2-oxo-heterocyclic compounds and pharmaceutical compositions | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2010-05-25 | — | — | US | disclosed |