Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.66 |
| ▸ | FOS | P01100 | 1/20 | 0.66 |
| ▸ | JUN | P05412 | 1/20 | 0.66 |
| ▸ | BCHE | P06276 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.61 |
| ▸ | MAOA | P21397 | 2/20 | 0.61 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.61 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.61 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31737429 | 1.00 | MAOB (0.66) | MAOBFOSJUNBCHEKDM4E | |
| SCHEMBL3290630 | 1.00 | MAOB (0.66) | MAOBFOSJUNBCHEKDM4E | |
| SCHEMBL30970401 | 1.00 | MAOB (0.66) | MAOBFOSJUNBCHEKDM4E | |
| SCHEMBL12698272 | 0.89 | MAOB (0.57) | MAOBFOSJUNBCHECYP1A2 | |
| Tetrahydrofuran SCHEMBL27547284 | 0.89 | ALDH1A1 (0.55) | MAOBFOSJUNBCHEKDM4E | |
| SCHEMBL18497044 | 0.89 | MAOB (0.64) | MAOBFOSJUNBCHEKDM4E | |
| SCHEMBL69618 | 0.88 | TTR (0.66) | FOSJUNKDM4EMEN1GAA | |
| SCHEMBL29455174 | 0.87 | MAOB (0.66) | MAOBFOSJUNBCHECYP1A2 | |
| SCHEMBL16588978 | 0.87 | MAOB (0.66) | MAOBFOSJUNBCHECYP1A2 | |
| SCHEMBL3580362 | 0.86 | FOS (0.79) | MAOBFOSJUNBCHECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884083-B | Benzo [ B ] furans as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2022-02-25 | — | — | CN | disclosed |
| CN-113164571-A | Inhibition of ubiquitin-specific peptidase 9X | 福马治疗股份有限公司 | 2021-07-23 | — | — | CN | disclosed |
| EP-3208301-B1 | RESIN COMPOSITION AND OPTICAL COMPENSATION FILM USING SAME | TOSOH CORP (JP) | 2019-04-03 | — | — | EP | disclosed |
| EP-3440075-A1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GlaxoSmithKline Intellectual Property (No. 2) Limited (GB) | 2019-02-13 | — | — | EP | disclosed |
| US-10126478-B2 | Resin composition and optical compensation film using same | TOSOH CORPORATION (JP) | 2018-11-13 | — | — | US | disclosed |
| WO-2017174620-A1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |
| US-20170242174-A1 | RESIN COMPOSITION AND OPTICAL COMPENSATION FILM USING SAME | TOSOH CORPORATION (JP) | 2017-08-24 | — | — | US | disclosed |
| EP-3208301-A1 | RESIN COMPOSITION AND OPTICAL COMPENSATION FILM USING SAME | Tosoh Corporation (JP) | 2017-08-23 | — | — | EP | disclosed |
| EP-2207540-B1 | CYCLOPROPYL ARYL AMIDE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2014-02-26 | — | — | EP | disclosed |
| EP-2207540-A1 | CYCLOPROPYL ARYL AMIDE DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2010-07-21 | — | — | EP | disclosed |
| EP-0143952-B1 | SUBSTITUTED CINNAMYL-2,3-DIHYDROBENZOPYRANS AND CINNAMYLPHENOLS USEFUL AS ANTI-INFLAMMATORY AGENTS | MERCK & CO. INC. (US) | 1993-01-13 | — | — | EP | disclosed |
| EP-0249301-B1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1992-05-27 | — | — | EP | disclosed |
| US-4952584-A | TREATMENT OF PROPHYLAXIS OF ANXIETY OR DEPRESSION | BEECHAM GROUP P.L.C. (GB) | 1990-08-28 | — | — | US | disclosed |
| US-4778818-A | VISION AND SKIN DISORDERS | MERCK & CO., INC. (US) | 1988-10-18 | — | — | US | disclosed |
| EP-0249301-A1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1987-12-16 | — | — | EP | disclosed |
| US-4686235-A | TOPICAL | MERCK & CO., INC. (US) | 1987-08-11 | — | — | US | disclosed |
| CN-85107235-A | As the replacement cinnamyl-2 of anti-inflammatory agent, the manufacture method of 3-Dihydrobenzofuranes and analogue | — | 1987-04-01 | — | — | CN | disclosed |
| US-4537903-A | Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents | MERCK & CO., INC. (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0143952-A1 | Substituted cinnamyl-2,3-dihydrobenzopyrans and cinnamylphenols useful as anti-inflammatory agents | MERCK & CO. INC. (US) | 1985-06-12 | — | — | EP | disclosed |
| US-4186142-A | Cyclization substrates and 6α-substituted 19-norsteroid derivatives | AKZONA INCORPORATED (US) | 1980-01-29 | — | — | US | disclosed |