Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NT5E | P21589 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6630142 | 0.96 | ADORA2A (0.60) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| Phosphoric Acid SCHEMBL5747244 | 0.87 | CYP2C19 (0.58) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| SCHEMBL14893125 | 0.84 | LMNA (0.58) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| SCHEMBL8425052 | 0.83 | LMNA (0.55) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| Phosphoric Acid SCHEMBL21465193 | 0.83 | LMNA (0.58) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| Phosphoric Acid SCHEMBL2829244 | 0.83 | HPGD (0.53) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| SCHEMBL343478 | 0.83 | CYP2C19 (0.62) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| SCHEMBL62505 | 0.83 | CYP2C19 (0.62) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| SCHEMBL18512921 | 0.83 | CYP2C19 (0.62) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| SCHEMBL14931005 | 0.83 | CYP2C19 (0.62) | ADORA2AADORA2BADORA3ADORA1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727737-B2 | Kit for rapid determination of thiopurine methyltransferase activity | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2010-06-01 | — | — | US | disclosed |
| US-20090029399-A1 | METHOD FOR RAPID DETERMINATION OF THIOPURINE METHYLTRANSFERASE ACTIVITY | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, A MINNESOTA CORPORATION | 2009-01-29 | — | — | US | disclosed |
| US-7452689-B2 | Method for rapid determination of thiopurine methyltransferase activity | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2008-11-18 | — | — | US | disclosed |
| US-20060263840-A1 | Method for rapid determination of thiopurine methyltransferase activity | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , A MINNESOTA CORPORATION | 2006-11-23 | — | — | US | disclosed |