Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 3/20 | 0.41 |
| ▸ | CCR2 | P41597 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3300426 | 0.99 | LMNA (0.41) | LMNAMAP3K14MEN1KMT2AALDH1A1 | |
| SCHEMBL4250940 | 0.88 | SLC6A2 (0.43) | LMNAMEN1KMT2AALDH1A1F10 | |
| SCHEMBL3295270 | 0.88 | F10 (0.47) | F10CCR2IKBKBCHUKPLA2G2A | |
| Hydrochloric Acid SCHEMBL3296621 | 0.87 | SLC6A2 (0.43) | LMNAMEN1KMT2AALDH1A1F10 | |
| Hydrochloric Acid SCHEMBL3297425 | 0.87 | F10 (0.46) | F10CCR2IKBKBCHUKPLA2G2A | |
| SCHEMBL3298326 | 0.86 | CCR2 (0.43) | LMNAMEN1KMT2AALDH1A1F10 | |
| SCHEMBL3298999 | 0.85 | SLC6A2 (0.38) | KMT2AALDH1A1F10CCR2ALK | |
| Hydrochloric Acid SCHEMBL3296434 | 0.85 | CCR2 (0.43) | LMNAMEN1KMT2AALDH1A1F10 | |
| Hydrochloric Acid SCHEMBL3299810 | 0.84 | SLC6A2 (0.38) | KMT2AALDH1A1F10CCR2ALK | |
| SCHEMBL3297575 | 0.84 | F10 (0.46) | ALDH1A1F10CCR2PLA2G2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084131-A1 | INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-08-05 | — | — | EP | claimed |
| WO-2008055808-A1 | INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | claimed |
| US-7741326-B2 | for enhancing cognitive memory in an Alzheimer's patient; 5-HT2-selective and 5-HT6 selective ligands | ROCHE PALO ALTO LLC (US) | 2010-06-22 | — | — | US | disclosed |
| US-7741326-B2 | for enhancing cognitive memory in an Alzheimer's patient; 5-HT2-selective and 5-HT6 selective ligands | ROCHE PALO ALTO LLC (US) | 2010-06-22 | — | — | US | disclosed |
| US-7741326-B2 | for enhancing cognitive memory in an Alzheimer's patient; 5-HT2-selective and 5-HT6 selective ligands | ROCHE PALO ALTO LLC (US) | 2010-06-22 | — | — | US | disclosed |
| US-20080146587-A1 | Indole and benzofuran 2-carboxamide derivatives and uses thereof | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
| US-20080146587-A1 | Indole and benzofuran 2-carboxamide derivatives and uses thereof | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
| US-20080146587-A1 | Indole and benzofuran 2-carboxamide derivatives and uses thereof | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
| WO-2008055808-A1 | INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146587-A1 | Indole and benzofuran 2-carboxamide derivatives and uses thereof | AR, CNR2, CNR1 | LMNA 1811/4885MAP3K14 3700/4885MEN1 698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.