Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 5/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL187306 | 0.94 | FFAR3 (0.37) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL973333 | 0.94 | FFAR3 (0.37) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL2368817 | 0.94 | FFAR3 (0.37) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL10692532 | 0.90 | CA12 (0.43) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Acetic Acid SCHEMBL27839914 | 0.88 | CA1 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL28836727 | 0.88 | CA12 (0.39) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Acetic Acid SCHEMBL9319465 | 0.88 | CA1 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Acetic Acid SCHEMBL27362312 | 0.88 | CA1 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL4871294 | 0.84 | FFAR3 (0.38) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL4244537 | 0.84 | CA4 (0.39) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306256-A1 | Salts in the Preparation of Cephalosporin Antibiodies | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2008-12-11 | — | — | US | claimed |
| EP-1765833-A2 | NEWS SALTS IN THE PREPARATION OF CEPHALOSPORIN ANTIBIOTICS | Orchid Chemicals and Pharmaceuticals Limited (IN) | 2007-03-28 | — | — | EP | claimed |
| WO-2006006040-A2 | NEWS DIAMINE SALTS OF CEPHALOSPORIN ANTIBIOTICS AND THEIR PREPARATION | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2006-01-19 | — | — | WO | claimed |
| JP-1193293-A | — | — | None | — | — | JP | disclosed |
| CN-109563050-A | Amide salt compound, for the catalyst of polyurethane production and the production method of polyurethane resin | 广荣化学工业株式会社 | 2019-04-02 | — | — | CN | disclosed |
| CN-104945451-B | synthesis method of l-borneol 2-O- β -D-glucopyranoside | 浙江工业大学 | 2018-06-26 | — | — | CN | disclosed |
| CN-107778271-A | Anticancer compound CX1409 synthetic method | 北京康辰药业股份有限公司 | 2018-03-09 | — | — | CN | disclosed |
| CN-107074845-A | The manufacture method of pyrazole derivatives | 持田制药株式会社 | 2017-08-18 | — | — | CN | disclosed |
| CN-107074844-A | The manufacture method of pyrazole derivatives | 持田制药株式会社 | 2017-08-18 | — | — | CN | disclosed |
| CN-105189476-B | Pyrazole derivatives | 帝人制药株式会社 | 2017-07-07 | — | — | CN | disclosed |
| CN-103483294-B | Salt of 3-amino-2-propanol acetamide compound, as well as preparation method and use thereof | UNIV SICHUAN | 2015-01-28 | — | — | CN | disclosed |
| WO-2009138847-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF CEFOZOPRAN | ORCHID CHEMICALS AND PHARMACEUTICALS LTD. (IN) | 2009-11-19 | — | — | WO | disclosed |
| US-20080306256-A1 | Salts in the Preparation of Cephalosporin Antibiodies | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2008-12-11 | — | — | US | disclosed |
| EP-1765833-A2 | NEWS SALTS IN THE PREPARATION OF CEPHALOSPORIN ANTIBIOTICS | Orchid Chemicals and Pharmaceuticals Limited (IN) | 2007-03-28 | — | — | EP | disclosed |
| EP-0841339-B1 | Vinylpyrrolidinon cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| WO-2006006040-A2 | NEWS DIAMINE SALTS OF CEPHALOSPORIN ANTIBIOTICS AND THEIR PREPARATION | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2006-01-19 | — | — | WO | disclosed |
| US-6294668-B1 | ANTIBACTERIAL ACTIVITY AGAINST BETA-LACTAM SENSITIVE AND RESISTANT GRAM-POSITIVE BACTERIA, SUCH AS STAPHYLOCOCCI, PNEUMOCOCCI, AND ENTEROCOCCI; USED IN THERAPY OF INFECTIOUS DISEASES CAUSED BY THOSE BACTERIA | HOFFMAN-LA ROCHE INC. | 2001-09-25 | — | — | US | disclosed |
| EP-0841339-A1 | Vinylpyrrolidinon cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-05-13 | — | — | EP | disclosed |
| JP-H01193293-A | RETINOIC ESTER OF MACROLIDE, ITS PRODUCTION AND COSMETIC COMPOSITION CONTAINING THE SAME | L'OREAL SA | 1989-08-03 | — | — | JP | disclosed |
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306256-A1 | Salts in the Preparation of Cephalosporin Antibiodies | ABCB11, SLC10A1, NISCH | FFAR3 4755/4885HDAC3 3021/4885HDAC1 2163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.