Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL973333 | 0.94 | FFAR3 (0.37) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL2368817 | 0.94 | FFAR3 (0.37) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL3296887 | 0.94 | FFAR3 (0.41) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL4244537 | 0.84 | CA4 (0.39) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL10692532 | 0.84 | CA12 (0.43) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL973334 | 0.84 | FFAR3 (0.38) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL4871294 | 0.84 | FFAR3 (0.38) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL28173490 | 0.84 | FFAR3 (0.38) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL3415283 | 0.84 | CA4 (0.39) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL60768 | 0.83 | FFAR3 (0.44) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 226 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076488-B1 | CARBAMOYLATION OF AMINES, THIOPHENOLS, MERCAPTANES AND PHENOLS EMPLOYING ORGANIC AZIDES | METKINEN CHEMISTRY OY (FI) | 2016-05-11 | — | — | EP | claimed |
| US-8779194-B2 | Carbamoylation of amines, thiophenols, mercaptanes and phenols employing organic azides | METKINEN CHEMISTRY OY (FI) | 2014-07-15 | — | — | US | claimed |
| US-20100093981-A1 | CARBAMOYLATION OF AMINES, THIOPHENOLS, MERCAPTANES AND PHENOLS EMPLOYING ORGANIC AZIDES | METKINEN CHEMISTRY OY (FI) | 2010-04-15 | — | — | US | claimed |
| EP-0704536-B1 | Method for the isolation and purification of nucleotid-activated sugars from biological sources | HOECHST AG (DE) | 1998-11-18 | — | — | EP | claimed |
| US-5811539-A | Process for isolating and purifying nucleotide-activated sugars from biological sources | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-22 | — | — | US | claimed |
| US-20260126454-A1 | MASS SPECTROMETRY ANALYSIS OF MARKERS FOR ALZHEIMER'S DISEASE | EMORY UNIVERSITY (US) | 2026-05-07 | — | — | US | disclosed |
| EP-3868384-B1 | CYCLIC DINUCLEOTIDES AS STING (STIMULATOR OF INTERFERON GENES) AGONISTS | TAKEDA PHARMACEUTICALS CO (JP) | 2026-02-25 | — | — | EP | disclosed |
| EP-3604326-B1 | PEPTIDE COMPOUND AND METHOD FOR PRODUCING SAME, COMPOSITION FOR SCREENING USE, AND METHOD FOR SELECTING PEPTIDE COMPOUND | FUJIFILM CORP (JP) | 2026-01-07 | — | — | EP | disclosed |
| US-12370263-B2 | Cyclic dinucleotide derivative based antibody-drug conjugates | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2025-07-29 | — | — | US | disclosed |
| US-20250205270-A1 | ANTIBODY-DRUG CONJUGATE PRECURSORS COMPRISING A CYCLIC DINUCLEOTIDE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2025-06-26 | — | — | US | disclosed |
| EP-4524154-A2 | ANTIBODY-DRUG CONJUGATES OF CYCLIC DINUCLEOTIDE DERIVATIVES | Daiichi Sankyo Company, Limited (JP) | 2025-03-19 | — | — | EP | disclosed |
| EP-4524146-A1 | MRNA CAP ANALOG AND METHOD FOR PRODUCING SAME, METHOD FOR PRODUCING MRNA, AND KIT | YAMASA CORPORATION (JP) | 2025-03-19 | — | — | EP | disclosed |
| US-4724233-A | VIRICIDES | STICHTING REGA VZW (BE) | 1988-02-09 | — | — | US | disclosed |
| EP-0253412-A2 | N-Phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases, methods for their preparation and pharmaceutical compositions therefrom with antiviral activity | Ceskoslovenska akademie ved (CS) | 1988-01-20 | — | — | EP | disclosed |
| EP-0234178-A1 | New 8-substituted derivatives of an anhydrooctonic acid, methods for their preparation, pharmaceutical preparations containing these and intermediates | Astra Läkemedel Aktiebolag (SE) | 1987-09-02 | — | — | EP | disclosed |
| WO-1987003878-A1 | NEW 8-SUBSTITUTED DERIVATIVES OF AN ANHYDROOCTONIC ACID, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THESE AND INTERMEDIATES | Astra Läkemedel Aktiebolag (SE) | 1987-07-02 | — | — | WO | disclosed |
| US-4659825-A | METABOLIC INHIBITORS CLEAVING PHOSPHOMONOESTER BONDS IN ENZYMES, CHEMOSTERITANTS-INSECTICIDES | CESKOSLOVENSKA AKADEMIE (CS) | 1987-04-21 | — | — | US | disclosed |
| EP-0205826-A2 | Phosphonylmethoxyalkyl adenines for the treatment of virus diseases | Stichting REGA V.Z.W. (BE) | 1986-12-30 | — | — | EP | disclosed |
| EP-0206459-A2 | 9-(Phosphonylmethoxyalkyl) adenines, method for their preparation and their use | Ceskoslovenska akademie ved (CS) | 1986-12-30 | — | — | EP | disclosed |
| US-4164403-A | Method for inhibiting plant growth | CIBA-GEIGY CORPORATION (US) | 1979-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12370263-B2 | Cyclic dinucleotide derivative based antibody-drug conjugates | STING1, CGAS, CDA | FFAR3 1622/4885HDAC3 4033/4885HDAC1 4286/4885 |
| US-20100093981-A1 | CARBAMOYLATION OF AMINES, THIOPHENOLS, MERCAPTANES AND PHENOLS EMPLOYING ORGANIC AZIDES | ALKBH1, CPS1, RNGTT | FFAR3 2903/4885HDAC3 903/4885HDAC1 1355/4885 |
| US-20260126454-A1 | MASS SPECTROMETRY ANALYSIS OF MARKERS FOR ALZHEIMER'S DISEASE | APP, BACE1, BACE2 | FFAR3 2825/4885HDAC3 4621/4885HDAC1 4739/4885 |
| US-20250205270-A1 | ANTIBODY-DRUG CONJUGATE PRECURSORS COMPRISING A CYCLIC DINUCLEOTIDE | STING1, CGAS, TLR9 | FFAR3 2632/4885HDAC3 4738/4885HDAC1 4481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.