Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 9/20 | 0.40 |
| ▸ | CNR1 | P21554 | 7/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10033204 | 1.00 | LMNA (0.41) | LMNAMAPK1HTTCNR2CNR1 | |
| SCHEMBL1129252 | 0.98 | LMNA (0.42) | LMNAMAPK1HTTCNR2CNR1 | |
| SCHEMBL27740921 | 0.98 | LMNA (0.42) | LMNAMAPK1HTTCNR2CNR1 | |
| SCHEMBL1129253 | 0.98 | LMNA (0.42) | LMNAMAPK1HTTCNR2CNR1 | |
| SCHEMBL20560076 | 0.92 | HCAR2 (0.39) | LMNAMAPK1HTTCNR2CNR1 | |
| SCHEMBL12785471 | 0.90 | GSTP1 (0.36) | LMNAMAPK1HTTCNR2CNR1 | |
| SCHEMBL17701378 | 0.86 | LMNA (0.40) | LMNAMAPK1HTTCNR2CNR1 | |
| SCHEMBL1123521 | 0.80 | MAPT (0.50) | LMNAMAPK1HTTCNR2CNR1 | |
| SCHEMBL933708 | 0.80 | TSHR (0.44) | MAPK1CNR2CNR1PPARGPPARD | |
| SCHEMBL1123523 | 0.80 | MAPT (0.50) | LMNAMAPK1HTTCNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593097-B1 | COMPOUNDS WITH A SKIN PIGMENTING ACTIVITY AND PHARMACEUTICAL OR COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI SPA (IT) | 2016-08-24 | — | — | EP | disclosed |
| EP-2593097-A1 | COMPOUNDS WITH A SKIN PIGMENTING ACTIVITY AND PHARMACEUTICAL OR COSMETIC COMPOSITIONS CONTAINING THEM | Giuliani S.p.A. (IT) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007572-A1 | COMPOUNDS WITH A SKIN PIGMENTING ACTIVITY AND PHARMACEUTICAL OR COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI S.P.A. (IT) | 2012-01-19 | — | — | WO | disclosed |
| EP-2407163-A1 | Compounds with a skin pigmenting activity and pharmaceutical or cosmetic compositions containing them | Giuliani S.p.A. (IT) | 2012-01-18 | — | — | EP | disclosed |