Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6763715 | 0.92 | CA9 (0.61) | KMT2AGAAMAPTTP53TDP1 | |
| SCHEMBL18017546 | 0.90 | KMT2A (0.57) | KMT2AGAAMAPTTP53TDP1 | |
| SCHEMBL7268 | 0.88 | KMT2A (0.68) | KMT2AGAAMAPTTP53TDP1 | |
| SCHEMBL20788482 | 0.87 | MAPT (0.58) | KMT2AGAAMAPTTP53TDP1 | |
| SCHEMBL20028497 | 0.87 | KMT2A (0.53) | KMT2AGAAMAPTTP53TDP1 | |
| SCHEMBL28625965 | 0.87 | KMT2A (0.67) | KMT2AGAAMAPTTP53TDP1 | |
| SCHEMBL20502190 | 0.87 | KMT2A (0.60) | KMT2AGAAMAPTTP53TDP1 | |
| SCHEMBL22896893 | 0.86 | KMT2A (0.65) | KMT2AGAAMAPTTP53TDP1 | |
| SCHEMBL5676831 | 0.86 | CHRNA7 (0.61) | KMT2AGAAMAPTTP53MEN1 | |
| SCHEMBL5340205 | 0.86 | CHRNA7 (0.61) | KMT2AGAAMAPTTP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113480522-A | Novel phenylpyrazole derivative and application thereof in hypoglycemic drugs | 守恒(厦门)医疗科技有限公司 | 2021-10-08 | — | — | CN | disclosed |
| CN-111320606-B | Benzopyrazolo ring derivatives and application thereof in antitumor drugs | 安徽实特医药科技有限公司 | 2021-07-27 | — | — | CN | disclosed |
| CN-111333629-B | phenyl-1H-pyrazole derivatives and application thereof in antitumor drugs | 颜建发 | 2021-03-05 | — | — | CN | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| CN-111333629-A | phenyl-1H-pyrazole derivatives and application thereof in antitumor drugs | 颜建发 | 2020-06-26 | — | — | CN | disclosed |
| CN-111320606-A | Benzopyrazolo ring derivatives and application thereof in antitumor drugs | 颜建发 | 2020-06-23 | — | — | CN | disclosed |
| US-8299072-B2 | Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-10-30 | — | — | US | disclosed |
| US-8299072-B2 | Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-10-30 | — | — | US | disclosed |
| US-8299072-B2 | Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-10-30 | — | — | US | disclosed |
| US-7998995-B2 | LXR and FXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100094006-A1 | NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-04-15 | — | — | US | disclosed |
| US-20100094006-A1 | NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-04-15 | — | — | US | disclosed |
| US-20100094006-A1 | NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-04-15 | — | — | US | disclosed |
| US-20100069367-A1 | LXR and FXR Modulators | EXELIXIS, INC. (US) | 2010-03-18 | — | — | US | disclosed |
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-4389406-A | ANTHELMINTICS | BEECHAM GROUP LIMITED (GB) | 1983-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069367-A1 | LXR and FXR Modulators | NR1H3, NR1H2, NR1H4 | KMT2A 3296/4885GAA 3209/4885MAPT 4713/4885 |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | KMT2A 4418/4885GAA 616/4885MAPT 562/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | KMT2A 4469/4885GAA 751/4885MAPT 330/4885 |
| US-20100094006-A1 | NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | CACNA1I, CACNA1C, ORAI1 | KMT2A 1636/4885GAA 3637/4885MAPT 1118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.