SCHEMBL329995

SCHEMBL329995

O=C(Nc1ccccc1C(F)(F)F)c1cc(Cl)ccc1O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TMPRSS4 Q9NRS4 13/20 0.73
KCNMA1 Q12791 2/20 0.62
KDM4E B2RXH2 1/20 0.62
P2RX1 P51575 3/20 0.60
P2RX4 Q99571 3/20 0.60
P2RX7 Q99572 3/20 0.60
MEN1 O00255 1/20 0.60
IKBKB O14920 1/20 0.60
CHUK O15111 1/20 0.60
KDR P35968 1/20 0.60
FLT3 P36888 1/20 0.60
KMT2A Q03164 1/20 0.60
MYLK Q15746 1/20 0.60
MAP4K5 Q9Y4K4 1/20 0.60
GRIK1 P39086 1/20 0.60
SLC2A1 P11166 1/20 0.60
SMN1; SMN2 Q16637 1/20 0.57
TAS1R3 Q7RTX0 1/20 0.56
TAS1R1 Q7RTX1 1/20 0.56
TAS1R2 Q8TE23 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30771738 1.00 TMPRSS4 (0.73) TMPRSS4KCNMA1KDM4EP2RX1P2RX4
SCHEMBL4264823 0.89 TMPRSS4 (0.72) TMPRSS4KCNMA1KDM4EP2RX1P2RX4
SCHEMBL14886017 0.88 TMPRSS4 (0.65) TMPRSS4KCNMA1KDM4EP2RX1P2RX4
SCHEMBL330187 0.88 TMPRSS4 (0.65) TMPRSS4KCNMA1P2RX1P2RX4P2RX7
SCHEMBL330371 0.87 TMPRSS4 (0.68) TMPRSS4KCNMA1P2RX1P2RX4P2RX7
SCHEMBL330413 0.84 TMPRSS4 (1.00) TMPRSS4KCNMA1P2RX1P2RX4P2RX7
SCHEMBL5066868 0.84 TMPRSS4 (0.81) TMPRSS4KCNMA1KDM4EP2RX1P2RX4
SCHEMBL28109668 0.83 SMN1; SMN2 (0.70) KCNMA1KDM4EP2RX1P2RX4P2RX7
SCHEMBL1704851 0.83 TMPRSS4 (0.67) TMPRSS4KCNMA1KDM4EP2RX1P2RX4
SCHEMBL1462989 0.82 GRIK1 (0.72) TMPRSS4KCNMA1KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240002332-A1 Small Molecule Inhibitors of SARS-CoV-2 Infections THE FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION 2024-01-04 US claimed
EP-3653303-B1 PIPETTE TIP RACK BIOTIX INC (US) 2025-02-26 EP disclosed
US-12201987-B2 Pipette tip rack BIOTIX, INC. (US) 2025-01-21 US disclosed
US-20240002332-A1 Small Molecule Inhibitors of SARS-CoV-2 Infections THE FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION 2024-01-04 US disclosed
US-11590490-B2 Pipette tips BIOTIX, INC. (US) 2023-02-28 US disclosed
WO-2022109148-A1 SMALL MOLECULE INHIBITORS OF SARS-COV-2 INFECTIONS THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2022-05-27 WO disclosed
EP-3628404-B1 PIPETTE TIP TRAYS BIOTIX INC (US) 2021-06-30 EP disclosed
EP-3831489-A1 PIPETTE TIPS Biotix, Inc. (US) 2021-06-09 EP disclosed
US-20210039086-A1 PIPETTE TIPS BIOTIX, INC. 2021-02-11 US disclosed
US-20210016290-A1 PIPETTE TIP RACK BIOTIX, INC. 2021-01-21 US disclosed
EP-1458419-A1 ANTIMICROBIAL CONTACT LENS CASE Novartis AG (CH) 2004-09-22 EP disclosed
EP-1352650-A1 INHIBITORS AGAINST THE PRODUCTION AND RELEASE OF INFLAMMATORY CYTOKINES Institute of Medicinal Molecular Design, Inc. (JP) 2003-10-15 EP disclosed
US-20030176530-A1 Antimicrobial contact lens case LINDLEY KAREN FRANCES (US) 2003-09-18 US disclosed
WO-2003049776-A1 ANTIMICROBIAL CONTACT LENS CASE NOVARTIS AG (CH) 2003-06-19 WO disclosed
US-20030108761-A1 Anti-bacterial paper products EDDLEMON TAMMY (US) 2003-06-12 US disclosed
WO-2001070189-A1 METHOD AND COMPOSITION FOR SKIN LIGHTENING APPLYING CARBOXYLIC ACIDS UNILEVER PLC (GB) 2001-09-27 WO disclosed
US-6138315-A Antimicrobial active compounds CHESEBROUGH-POND'S USA CO., DIVISON OF CONOPCO, INC. (US) 2000-10-31 US disclosed
US-5919152-A Antibacterial swabs CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. (US) 1999-07-06 US disclosed
US-5846215-A Antibacterial swabs CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. (US) 1998-12-08 US disclosed
US-4022880-A ZINC IONS, 3,4,5-TRIBROMO-SALICYLANILIDE, QUATERNARY AMMONIUM COMPOUNDS LEVER BROTHERS COMPANY (US) 1977-05-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240002332-A1 Small Molecule Inhibitors of SARS-CoV-2 Infections ACE2, ACE, TMPRSS2 TMPRSS4 14/4885KCNMA1 3777/4885KDM4E 3140/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.