Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Xylometazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 7/20 | 0.97 |
| ▸ | ADRA2B known ✓ | P18089 | 6/20 | 0.97 |
| ▸ | ADRA2C known ✓ | P18825 | 6/20 | 0.97 |
| ▸ | ADRA1D known ✓ | P25100 | 5/20 | 0.97 |
| ▸ | ADRA1A known ✓ | P35348 | 5/20 | 0.97 |
| ▸ | ADRA1B known ✓ | P35368 | 5/20 | 0.97 |
| ▸ | HTR1D | P28221 | 12/20 | 0.97 |
| ▸ | HTR1B | P28222 | 10/20 | 0.97 |
| ▸ | HTR1A | P08908 | 4/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.97 |
| ▸ | TSHR | P16473 | 3/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.97 |
| ▸ | HTR2A | P28223 | 2/20 | 0.97 |
| ▸ | HTR2C | P28335 | 2/20 | 0.97 |
| ▸ | DRD3 | P35462 | 2/20 | 0.97 |
| ▸ | HTR2B | P41595 | 2/20 | 0.97 |
| ▸ | TP53 | P04637 | 1/20 | 0.97 |
| ▸ | DRD2 | P14416 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Xylometazoline SCHEMBL34087 | 0.98 | HTR1D (1.00) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL3299510 | 0.97 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL41837 | 0.97 | HTR1A (1.00) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL3297417 | 0.97 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL871223 | 0.97 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL6436975 | 0.95 | HTR1A (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL3301402 | 0.90 | HTR1D (0.84) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL3304354 | 0.90 | HTR1D (0.84) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL3300203 | 0.90 | HTR1D (0.84) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| SCHEMBL8149986 | 0.89 | HTR1D (1.00) | HTR1DHTR1BADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450339-B2 | Compositions for treatment of common cold | TAKEDA PHARMA A/S (DK) | 2013-05-28 | — | — | US | claimed |
| US-20100093783-A1 | Composition for treatment of common cold | TAKEDA PHARMA A/S (DK) | 2010-04-15 | — | — | US | claimed |
| US-8450339-B2 | Compositions for treatment of common cold | TAKEDA PHARMA A/S (DK) | 2013-05-28 | — | — | US | disclosed |
| US-20100093783-A1 | Composition for treatment of common cold | TAKEDA PHARMA A/S (DK) | 2010-04-15 | — | — | US | disclosed |
| US-7652030-B2 | Acidic aqueous solution containing ipratropium and xylometazoline | NYCOMED DANMARK APS (DK) | 2010-01-26 | — | — | US | disclosed |