Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Xylometazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 7/20 | 1.00 |
| ▸ | ADRA2B known ✓ | P18089 | 6/20 | 1.00 |
| ▸ | ADRA2C known ✓ | P18825 | 6/20 | 1.00 |
| ▸ | ADRA1D known ✓ | P25100 | 5/20 | 1.00 |
| ▸ | ADRA1A known ✓ | P35348 | 5/20 | 1.00 |
| ▸ | ADRA1B known ✓ | P35368 | 5/20 | 1.00 |
| ▸ | HTR1D | P28221 | 12/20 | 1.00 |
| ▸ | HTR1B | P28222 | 10/20 | 1.00 |
| ▸ | HTR1A | P08908 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Xylometazoline SCHEMBL41837 | 0.98 | HTR1A (1.00) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL3300993 | 0.98 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL3299510 | 0.98 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL3297417 | 0.98 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL871223 | 0.98 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL6436975 | 0.97 | HTR1A (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL3301402 | 0.92 | HTR1D (0.84) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL3304354 | 0.92 | HTR1D (0.84) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Xylometazoline SCHEMBL3300203 | 0.92 | HTR1D (0.84) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| SCHEMBL8149986 | 0.91 | HTR1D (1.00) | HTR1DHTR1BADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8393 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260108531-A1 | Methods of Treating Hypogonadism with Transnasal Testosterone Bio-adhesive Gel Formulations in Males with Allergic Rhinitis and Methods for Preventing an Allergic Rhinitis Event | ACERUS BIOPHARMA INC (CA) | 2026-04-23 | — | — | US | claimed |
| EP-4724079-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION | Stealth BioTherapeutics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| EP-4704839-A2 | IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF | ALPHERABIO LLC (US) | 2026-03-11 | — | — | EP | claimed |
| US-20260048096-A1 | METHODS AND COMPOSITIONS FOR PRESERVING THE RETINAL OUTER NUCLEAR LAYER (ONL), PHOTORECEPTORS, AND RETINAL THICKNESS | STEALTH BIOTHERAPEUTICS INC. (US) | 2026-02-19 | — | — | US | claimed |
| US-20250255755-A1 | WOUND HEALING DEVICE AND METHODS FOR WOUND HEALING | SINUS CLEAR INNOVATIONS LLC (US) | 2025-08-14 | — | — | US | claimed |
| EP-4404916-B1 | AN IMPROVED PHARMACEUTICAL COMPOSITION FOR NASAL USE, PREPARATION, AND USE THEREOF | JADRAN GALENSKI LABORATORIJ D D (HR) | 2025-08-06 | — | — | EP | claimed |
| EP-4596049-A2 | PEPTIDE FOR USE IN PREVENTING OR TREATING MACULAR DEGENERATION | Stealth BioTherapeutics Inc. (US) | 2025-08-06 | — | — | EP | claimed |
| US-12377075-B2 | Device for internal and external nasal application | HALEON CH SARL (CH) | 2025-08-05 | — | — | US | claimed |
| US-20250235641-A1 | DEVICE TO DELIVER A PREDETERMINED AMOUNT OF A SUBSTANCE TO A NATURAL ORIFICE OF THE BODY | APTARGROUP INC. (US) | 2025-07-24 | — | — | US | claimed |
| US-4741899-A | Process for arresting the proliferation of organisms that convert axillary secretions to malodorous materials | BRISTOL-MYERS COMPANY (US) | 1988-05-03 | — | — | US | claimed |
| US-4737361-A | Alpha adrenergic amine of substantial alpha2 adrenergic amine activity as an antiperspirant | BRISTOL-MYERS COMPANY (US) | 1988-04-12 | — | — | US | claimed |
| EP-0086428-B1 | ANTIDIARRHOEA VETERINARY COMPOSITION, ITS PRODUCTION AND ORAL DOSER CONTAINING IT | BEECHAM GROUP PLC (GB) | 1987-07-29 | — | — | EP | claimed |
| US-4603131-A | Method and composition for treating and preventing irritation of the mucous membranes of the nose | BERNSTEIN, JOEL E. | 1986-07-29 | — | — | US | claimed |
| EP-0025269-B1 | ANTI-DIARRHOEA VETERINARY COMPOSITION | BEECHAM GROUP PLC (GB) | 1985-11-13 | — | — | EP | claimed |
| EP-0082546-B1 | PHARMACEUTICAL MIXTURE AND METHOD FOR MAKING THE MIXTURE | FISONS plc (GB) | 1985-08-14 | — | — | EP | claimed |
| EP-0086428-A1 | Antidiarrhoea veterinary composition, its production and oral doser containing it | BEECHAM GROUP PLC (GB) | 1983-08-24 | — | — | EP | claimed |
| EP-0082546-A1 | Pharmaceutical mixture and method for making the mixture | FISONS plc (GB) | 1983-06-29 | — | — | EP | claimed |
| US-4255439-A | Means and method for aiding individuals to stop smoking | COOPER IRVING | 1981-03-10 | — | — | US | claimed |
| US-3933999-A | 1-METHYL-2-(2-(ALPHA-METHYL-P -CHLORODIPHENYLMETHOXY)ETHYL)PYRROLIDONE, RHINITIS, VASOCONSTRICTOR | SANDOZ LTD., (SANDOZ AG) (CH) | 1976-01-20 | — | — | US | claimed |