Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | HNF4A | P41235 | 2/20 | 0.44 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2185735 | 0.86 | GABRA1 (0.82) | GABRA1GABRB2ALOX5AKR1B1HNF4A | |
| SCHEMBL9195243 | 0.84 | GABRA1 (0.85) | GABRA1GABRB2ALOX5AKR1B1MEN1 | |
| SCHEMBL5406886 | 0.83 | GABRA1 (0.55) | GABRA1GABRB2ALOX5AKR1B1MEN1 | |
| SCHEMBL5306483 | 0.82 | ALOX5 (0.52) | ALOX5HNF4AACMSDMEN1GAA | |
| 2-Allylphenol SCHEMBL3748522 | 0.81 | GABRA1 (0.62) | GABRA1GABRB2ALOX5AKR1B1MEN1 | |
| SCHEMBL28541485 | 0.80 | GABRA1 (0.47) | GABRA1GABRB2ALOX5AKR1B1MEN1 | |
| SCHEMBL3924845 | 0.79 | ALOX5 (0.57) | ALOX5HNF4AACMSDMEN1GAA | |
| SCHEMBL27889219 | 0.79 | GABRA1 (0.56) | GABRA1GABRB2ALOX5AKR1B1MEN1 | |
| SCHEMBL51661 | 0.79 | ALOX5 (0.61) | ALOX5HNF4AACMSDMEN1GAA | |
| SCHEMBL29059236 | 0.77 | ALOX5 (0.59) | ALOX5HNF4AACMSDMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738661-B2 | HCV NS3 protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-22 | — | — | US | disclosed |
| US-20150266897-A1 | HCV NS3 Protease Inhibitors | MSD ITALIA S.R.L. (IT) | 2015-09-24 | — | — | US | disclosed |
| US-20100099695-A1 | HCV NS3 Protease Inhibitors | MSD ITALIA S.R.L. (IT) | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099695-A1 | HCV NS3 Protease Inhibitors | HAVCR2, GTF3C3, CTSC | GABRA1 4311/4885GABRB2 4252/4885ALOX5 2533/4885 |
| US-20150266897-A1 | HCV NS3 Protease Inhibitors | HAVCR2, GTF3C3, CTSC | GABRA1 4311/4885GABRB2 4252/4885ALOX5 2533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.