Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410743 | 0.99 | LMNA (0.47) | LMNAPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL410417 | 0.88 | ALDH1A1 (0.55) | LMNAALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL3301869 | 0.88 | PTGS1 (0.49) | LMNAPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL17225374 | 0.87 | LMNA (0.45) | LMNAPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL411526 | 0.87 | ALDH1A1 (0.56) | LMNAALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL411478 | 0.86 | ALDH1A1 (0.45) | LMNAPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL406868 | 0.84 | PTGS1 (0.57) | LMNAPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL411865 | 0.83 | PTGS1 (0.56) | LMNAPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL413249 | 0.83 | LMNA (0.41) | LMNAPTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4660911 | 0.82 | POLB (0.42) | LMNAPTGS1PTGS2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100093670-A1 | Compounds for the treatment of angiogenesis | SYNTA PHARMACEUTICALS CORP. | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093670-A1 | Compounds for the treatment of angiogenesis | FLT4, FLT1, TEK | LMNA 4831/4885PTGS1 36/4885PTGS2 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.