Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP4 | P49662 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CASP9 | P55211 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18786857 | 0.90 | MAPT (0.47) | MAPTALDH1A1LMNAGABRA1GABRG2 | |
| SCHEMBL31351788 | 0.82 | ALDH1A1 (0.45) | MAPTALDH1A1LMNAGABRA1GABRG2 | |
| SCHEMBL29338553 | 0.81 | PIK3CA (0.47) | LMNAPIK3CAMTORESR2NR1H2 | |
| SCHEMBL21461289 | 0.81 | ESR2 (0.53) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2144223 | 0.80 | CA9 (0.46) | MAPTALDH1A1LMNACASP1CASP3 | |
| SCHEMBL2144236 | 0.80 | CA9 (0.46) | MAPTALDH1A1LMNACASP1CASP3 | |
| Acetic Acid SCHEMBL31351752 | 0.80 | MAPT (0.42) | MAPTALDH1A1LMNAGABRA1GABRG2 | |
| SCHEMBL17141692 | 0.80 | PIK3CA (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18863339 | 0.80 | PIK3CA (0.46) | PIK3CAMTORESR2NR1H2ACHE | |
| SCHEMBL2145067 | 0.80 | NR1H2 (0.54) | ALDH1A1PIK3CAMTORDRD2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117777134-B | Polycyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2025-02-25 | — | — | CN | disclosed |
| CN-117777134-A | Polycyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-116425751-B | Polycyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-116425751-A | Polycyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |
| US-20130005707-A1 | AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | BAHMANYAR SOGOLE (US) | 2013-01-03 | — | — | US | disclosed |
| US-8299056-B2 | Aminotriazolopyridines, compositions thereof, and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2012-10-30 | — | — | US | disclosed |
| US-20100093698-A1 | AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130005707-A1 | AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | MAP3K2, MAP3K1, MAP3K3 | MAPT 1496/4885ALDH1A1 1694/4885LMNA 2134/4885 |
| US-20100093698-A1 | AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | MAP3K2, MAP3K1, MAP3K3 | MAPT 1496/4885ALDH1A1 1694/4885LMNA 2134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.