Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KLK7 | P49862 | 1/20 | 0.30 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790633 | 0.78 | KLK7 (0.34) | KLK7KLK5 | |
| SCHEMBL4429712 | 0.67 | NFKB1 (0.30) | — | |
| SCHEMBL3303460 | 0.67 | NFKB1 (0.30) | — | |
| SCHEMBL3306620 | 0.67 | NFKB1 (0.30) | — | |
| SCHEMBL4792299 | 0.65 | NFKB1 (0.38) | GAAKLK7KLK5 | |
| SCHEMBL3692487 | 0.63 | NFKB1 (0.32) | — | |
| SCHEMBL3302910 | 0.63 | NFKB1 (0.32) | — | |
| SCHEMBL13391320 | 0.61 | NFKB1 (0.30) | — | |
| SCHEMBL34475689 | 0.60 | CHRM2 (0.38) | KDM4ESMN1; SMN2KLK7KLK5 | |
| SCHEMBL14515887 | 0.60 | CHRM2 (0.38) | KDM4ESMN1; SMN2KLK7KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592587-B2 | Transannular rearrangement of activated lactams | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2013-11-26 | — | — | US | disclosed |
| EP-2134681-B1 | TRANS-ANNULAR REARRANGEMENT OF ACTIVE LACTAMES | CENTRE NAT RECH SCIENT (FR) | 2012-05-16 | — | — | EP | disclosed |
| EP-2134681-B1 | TRANS-ANNULAR REARRANGEMENT OF ACTIVE LACTAMES | CENTRE NAT RECH SCIENT (FR) | 2012-05-16 | — | — | EP | disclosed |
| US-20100099874-A1 | TRANSANNULAR REARRANGEMENT OF ACTIVATED LACTAMS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS (FR) | 2010-04-22 | — | — | US | disclosed |
| US-20100099874-A1 | TRANSANNULAR REARRANGEMENT OF ACTIVATED LACTAMS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS (FR) | 2010-04-22 | — | — | US | disclosed |
| WO-2008125421-A1 | TRANS-ANNULAR REARRANGEMENT OF ACTIVE LACTAMES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099874-A1 | TRANSANNULAR REARRANGEMENT OF ACTIVATED LACTAMS | C9, RPS4Y1, C5 | GAA 3342/4885KDM4E 3649/4885SMN1; SMN2 3853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.