Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 9/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | GPR3 | P46089 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28563540 | 0.81 | MAPT (0.60) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL30987223 | 0.81 | MAPT (0.60) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL3150476 | 0.79 | MAPT (0.46) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL407272 | 0.71 | KDM4E (0.31) | KDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL6964514 | 0.70 | KDM4E (0.52) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL29610220 | 0.67 | KDM4E (0.41) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL5007 | 0.66 | GPR3 (0.54) | KDM4EMAPTALDH1A1GPR3 | |
| SCHEMBL24566449 | 0.66 | MAPT (0.47) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL2409495 | 0.65 | CYP2A6 (0.33) | ALDH1A1HSD17B10GPR3 | |
| SCHEMBL3626867 | 0.64 | MAPT (0.42) | KDM4EMAPTALDH1A1HSD17B10EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097759-B2 | Inflammatory cytokine release inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2012-01-17 | — | — | US | disclosed |