Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.61 |
| ▸ | CACNA1G | O43497 | 8/20 | 0.61 |
| ▸ | CACNA1H | O95180 | 8/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3299252 | 0.92 | KCNH2 (0.61) | KCNH2CACNA1GCACNA1HALOX5HTR6 | |
| SCHEMBL3301665 | 0.92 | KCNH2 (0.59) | KCNH2CACNA1GCACNA1HPOLBHTR6 | |
| SCHEMBL3299904 | 0.90 | ALOX5 (0.51) | KCNH2CACNA1GCACNA1HALOX5POLB | |
| SCHEMBL3306921 | 0.87 | KCNH2 (0.61) | KCNH2CACNA1GCACNA1HHTR6 | |
| SCHEMBL3298599 | 0.87 | POLB (0.52) | ALOX5POLBACHEL3MBTL1HIF1A | |
| SCHEMBL16783997 | 0.84 | CYP2D6 (0.49) | KCNH2CACNA1GCACNA1H | |
| SCHEMBL16783999 | 0.84 | CYP2D6 (0.49) | KCNH2CACNA1GCACNA1H | |
| SCHEMBL16783995 | 0.84 | CYP2D6 (0.49) | KCNH2CACNA1GCACNA1H | |
| SCHEMBL3300454 | 0.84 | CACNA1G (0.60) | KCNH2CACNA1GCACNA1HHTR6 | |
| SCHEMBL3306574 | 0.84 | CACNA1G (0.57) | KCNH2CACNA1GCACNA1HPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299072-B2 | Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-10-30 | — | — | US | claimed |
| US-20100094006-A1 | NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-04-15 | — | — | US | claimed |
| US-8299072-B2 | Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-10-30 | — | — | US | disclosed |
| US-20100094006-A1 | NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100094006-A1 | NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | CACNA1I, CACNA1C, ORAI1 | KCNH2 69/4885CACNA1G 7/4885CACNA1H 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.