Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3302610 | 0.86 | CYP3A4 (0.49) | THRBKCNA3CYP3A4MAPK1USP2 | |
| SCHEMBL4255276 | 0.84 | ALDH1A1 (0.59) | THRBKCNA3CYP3A4MAPK1USP2 | |
| SCHEMBL111734 | 0.83 | TDP1 (0.50) | THRBKCNA3CYP3A4MAPK1USP2 | |
| SCHEMBL13835746 | 0.83 | KDM4E (0.52) | CA9CA1CA12CA7CA2 | |
| SCHEMBL30803084 | 0.83 | KDM4E (0.52) | CA9CA1CA12CA7CA2 | |
| SCHEMBL6243537 | 0.81 | CA1 (0.54) | THRBKCNA3CYP3A4MAPK1USP2 | |
| SCHEMBL313564 | 0.79 | CA1 (0.40) | THRBKCNA3CYP3A4MAPK1USP2 | |
| SCHEMBL28436043 | 0.79 | HMGCR (0.46) | THRBKCNA3CYP3A4MAPK1PRKCI | |
| SCHEMBL6451162 | 0.78 | THRB (0.70) | THRBCYP3A4MAPK1USP2SMN1; SMN2 | |
| SCHEMBL3258548 | 0.77 | ALDH1A1 (0.53) | KCNA3CYP3A4MAPK1SMN1; SMN2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946287-B2 | Chemotherapeutic flavonoids, and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946287-B2 | Chemotherapeutic flavonoids, and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946287-B2 | Chemotherapeutic flavonoids, and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2015-02-03 | — | — | US | disclosed |
| US-20100099755-A1 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2010-04-22 | — | — | US | disclosed |
| US-20100099755-A1 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2010-04-22 | — | — | US | disclosed |
| US-20100099755-A1 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2010-04-22 | — | — | US | disclosed |
| WO-2008076767-A1 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076767-A1 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2007070986-A1 | FLAVONES | ECOBIOTICS LIMITED (AU) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099755-A1 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF | NRAS, FAU, DPYD | THRB 4699/4885KCNA3 4573/4885CYP3A4 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.