Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 9/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | TPO | P07202 | 1/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 5/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3308708 | 0.85 | HPGD (0.51) | CYP3A4HPGD | |
| SCHEMBL3308176 | 0.81 | CYP3A4 (0.42) | CYP3A4CYP1A1 | |
| SCHEMBL2363467 | 0.80 | CYP3A4 (0.43) | CYP3A4CD274PDCD1CYP1A1HPGD | |
| SCHEMBL2362967 | 0.79 | CYP3A4 (0.50) | CYP3A4CD274PDCD1CYP1A1HPGD | |
| SCHEMBL2364475 | 0.79 | CYP3A4 (0.42) | CYP3A4CYP1A1 | |
| SCHEMBL2362428 | 0.78 | CYP3A4 (0.44) | CYP3A4CYP1A1TDP1HPGD | |
| SCHEMBL2352735 | 0.78 | CYP3A4 (0.45) | CYP3A4CYP1A1 | |
| SCHEMBL2363082 | 0.78 | HTR2A (0.44) | CYP3A4CD274CYP1A1HPGD | |
| SCHEMBL2354460 | 0.78 | EPHX2 (0.44) | CYP3A4HPGDSMN1; SMN2 | |
| SCHEMBL3372409 | 0.77 | HPGD (0.41) | CYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232271-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2012-07-31 | — | — | US | claimed |
| US-20100111900-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | ROCHE PALO ALTO LLC | 2010-05-06 | — | — | US | claimed |
| WO-2010049331-A1 | HETEROCYCLIC ANTIVIRAL ARYLPYRIDONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100111900-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | POLR2A, EIF2AK2, POLR2B | CYP3A4 423/4885CD274 3932/4885PDCD1 3638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.