Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.81 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.60 |
| ▸ | PI4KA | P42356 | 7/20 | 0.60 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11414056 | 0.90 | CYP3A4 (1.00) | CYP3A4PIK3CAPI4KAPI4KBCYP2D6 | |
| SCHEMBL28364480 | 0.85 | CYP3A4 (0.81) | CYP3A4PIK3CAPI4KAPI4KBCYP2D6 | |
| SCHEMBL1847514 | 0.82 | PIK3CA (0.70) | CYP3A4PIK3CAPI4KAPI4KBPIK3CD | |
| SCHEMBL1853965 | 0.81 | CYP3A4 (0.62) | CYP3A4PIK3CAPI4KAPI4KBPIK3CD | |
| SCHEMBL13412968 | 0.80 | CYP3A4 (0.63) | CYP3A4PIK3CAPI4KAPI4KBPIK3CD | |
| SCHEMBL24133664 | 0.79 | CYP3A4 (0.70) | CYP3A4CA12CA1CA2CA7 | |
| SCHEMBL27812091 | 0.77 | CYP3A4 (0.76) | CYP3A4PIK3CAPI4KAPI4KBCYP2D6 | |
| SCHEMBL8773471 | 0.77 | PIK3CA (1.00) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL29752153 | 0.75 | CYP3A4 (0.68) | CYP3A4PIK3CAPI4KAPI4KBCYP2D6 | |
| SCHEMBL16151069 | 0.75 | CYP3A4 (0.72) | CYP3A4CYP2D6CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420052-B2 | Imaging agents useful for identifying AD pathology | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2013-04-16 | — | — | US | disclosed |
| US-8420052-B2 | Imaging agents useful for identifying AD pathology | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2013-04-16 | — | — | US | disclosed |
| US-20100098634-A1 | Imaging Agents Useful for Identifying AD Pathology | SIEMENS MEDICAL SOLUTIONS USA, INC. | 2010-04-22 | — | — | US | disclosed |
| US-20100098634-A1 | Imaging Agents Useful for Identifying AD Pathology | SIEMENS MEDICAL SOLUTIONS USA, INC. | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100098634-A1 | Imaging Agents Useful for Identifying AD Pathology | APP, APBA1, PYGB | CYP3A4 4593/4885PIK3CA 4138/4885PI4KA 4376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.