SCHEMBL3310182

SCHEMBL3310182

Nc1n[nH]c(N)c1N=Nc1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNE1 P24864 9/20 1.00
CDK2 P24941 9/20 1.00
CCNE2 O96020 7/20 1.00
CCNT1 O60563 5/20 1.00
CDK9 P50750 5/20 1.00
CDK4 P11802 3/20 1.00
CCND1 P24385 3/20 1.00
CDK7 P50613 3/20 1.00
CCNH P51946 3/20 1.00
CDK1 P06493 2/20 1.00
CCNB1 P14635 2/20 1.00
CCNT2 O60583 1/20 1.00
CCNB2 O95067 1/20 1.00
CCNA2 P20248 1/20 1.00
RPS6KB1 P23443 1/20 1.00
CCNA1 P78396 1/20 1.00
CCNB3 Q8WWL7 1/20 1.00
RPS6KB2 Q9UBS0 1/20 1.00
GAA P10253 7/20 0.71
MAPT P10636 7/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12589685 1.00 CCNE1 (1.00) CCNE1CDK2CCNE2CCNT1CDK9
SCHEMBL4882905 0.86 CCNE1 (0.75) CCNE1CDK2CCNE2CCNT1CDK9
SCHEMBL4882884 0.86 CCNE1 (0.75) CCNE1CDK2CCNE2CCNT1CDK9
SCHEMBL3837502 0.83 CCNE1 (0.71) CCNE1CDK2CCNE2CCNT1CDK9
SCHEMBL3836624 0.83 MAPT (1.00) CCNE1CDK2CCNE2CCNT1CDK9
SCHEMBL3836615 0.83 MAPT (1.00) CCNE1CDK2CCNE2CCNT1CDK9
SCHEMBL3839801 0.83 GAA (1.00) CCNE1CDK2CCNE2CCNT1CDK9
SCHEMBL3837703 0.83 MAPT (0.71) CCNE1CDK2CCNE2CCNT1CDK9
SCHEMBL3837556 0.82 CCNE1 (1.00) CCNE1CDK2CCNE2CCNT1CDK9
SCHEMBL3837559 0.82 CCNE1 (1.00) CCNE1CDK2CCNE2CCNT1CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240299558-A1 PROTEOLYSIS TARGETING CHIMERAS AND POLYPHARMACOLOGICAL AGENTS TARGETING BCL-2, AND METHODS OF USE THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-09-12 US claimed
US-20240293557-A1 PROTEOLYSIS TARGETING CHIMERAS AND METHODS OF USE THEREOF UNIVERSITY OF MARYLAND, BALTIMORE 2024-09-05 US claimed
US-20230293414-A1 USE OF CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS FOR THE SLOWDOWN OR PREVENTION OF BIOLOGICAL AGING HOPE PERMANENTE LLC (US) 2023-09-21 US claimed
EP-4192463-A1 USE OF CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS FOR THE SLOWDOWN OR PREVENTION OF BIOLOGICAL AGING Hope Permanente, LLC (US) 2023-06-14 EP claimed
US-20230109457-A1 USE OF CDK9 INHIBITORS TO REDUCE CARTILAGE DEGRADATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-04-06 US claimed
WO-2022266491-A1 PROTEOLYSIS TARGETING CHIMERAS AND POLYPHARMACOLOGICAL AGENTS TARGETING BCL-2, AND METHODS OF USE THEREOF UNIVERSITY OF MARYLAND, BALTIMORE (US) 2022-12-22 WO claimed
WO-2022261220-A1 PROTEOLYSIS TARGETING CHIMERAS AND METHODS OF USE THEREOF UNIVERSITY OF MARYLAND, BALTIMORE (US) 2022-12-15 WO claimed
US-11351161-B2 Use of CDK9 inhibitors to reduce cartilage degradation THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-06-07 US claimed
CN-107904201-B Differentiation of human embryonic stem cells into the pancreatic endocrine lineage 詹森生物科技公司 2021-11-16 CN claimed
US-11020404-B2 Use of CDK9 and BRD4 inhibitors to inhibit inflammation The Regents of the University of California, Davis (US) 2021-06-01 US claimed
US-20210008054-A1 USE OF CDK9 INHIBITORS TO REDUCE CARTILAGE DEGRADATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-01-14 US claimed
US-10639302-B2 Use of CDK9 inhibitors to reduce cartilage degradation THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-05-05 US claimed
US-20200046726-A1 USE OF CDK9 AND BRD4 INHIBITORS TO INHIBIT INFLAMMATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-02-13 US claimed
US-20190255034-A1 USE OF CDK9 INHIBITORS TO REDUCE CARTILAGE DEGRADATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-08-22 US claimed
US-10172844-B2 Use of CDK9 inhibitors to reduce cartilage degradation THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-01-08 US claimed
EP-2346988-B1 DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO THE PANCREATIC ENDOCRINE LINEAGE JANSSEN BIOTECH INC (US) 2017-05-31 EP claimed
EP-1786779-B1 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF INST OF EX BOTANY OF THE ASCR (CZ) 2009-10-28 EP claimed
US-20080312238-A1 4-Arylazo-3,5-Diamino-Pyrazole Compounds and Use Thereof INSTITUTE OF EXPERIMENTAL BONTANY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC, V.V.I. (CZ) 2008-12-18 US claimed
EP-1786779-A1 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2007-05-23 EP claimed
WO-2006024858-A1 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF INSTITUTE OF EXPERIMENTAL BOTANY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2006-03-09 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200046726-A1 USE OF CDK9 AND BRD4 INHIBITORS TO INHIBIT INFLAMMATION CDK9, BRD4, CDK19 CCNE1 83/4885CDK2 11/4885CCNE2 116/4885
US-20240299558-A1 PROTEOLYSIS TARGETING CHIMERAS AND POLYPHARMACOLOGICAL AGENTS TARGETING BCL-2, AND METHODS OF USE THEREOF BCL3, MCL1, BCL2 CCNE1 1783/4885CDK2 741/4885CCNE2 2719/4885
US-11020404-B2 Use of CDK9 and BRD4 inhibitors to inhibit inflammation CDK9, BRD4, CDK19 CCNE1 83/4885CDK2 11/4885CCNE2 116/4885
US-20080312238-A1 4-Arylazo-3,5-Diamino-Pyrazole Compounds and Use Thereof CDK9, CDK3, CDK19 CCNE1 93/4885CDK2 13/4885CCNE2 279/4885
US-20240293557-A1 PROTEOLYSIS TARGETING CHIMERAS AND METHODS OF USE THEREOF MCL1, BCL3, CRBN CCNE1 1814/4885CDK2 1951/4885CCNE2 3867/4885
US-20230109457-A1 USE OF CDK9 INHIBITORS TO REDUCE CARTILAGE DEGRADATION CDK9, CDK19, CDKN1A CCNE1 53/4885CDK2 8/4885CCNE2 79/4885
US-20210008054-A1 USE OF CDK9 INHIBITORS TO REDUCE CARTILAGE DEGRADATION CDK9, CDK19, CDKN1A CCNE1 53/4885CDK2 8/4885CCNE2 79/4885
US-20190255034-A1 USE OF CDK9 INHIBITORS TO REDUCE CARTILAGE DEGRADATION CDK9, CDK19, CDKN1A CCNE1 53/4885CDK2 8/4885CCNE2 79/4885
US-11351161-B2 Use of CDK9 inhibitors to reduce cartilage degradation CDK9, CDK19, CDKN1A CCNE1 53/4885CDK2 8/4885CCNE2 79/4885
US-10172844-B2 Use of CDK9 inhibitors to reduce cartilage degradation CDK9, CDK19, CDKN1A CCNE1 53/4885CDK2 8/4885CCNE2 79/4885
US-10639302-B2 Use of CDK9 inhibitors to reduce cartilage degradation CDK9, CDK19, CDKN1A CCNE1 53/4885CDK2 8/4885CCNE2 79/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.