Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3314258 | 0.80 | NPFFR1 (0.39) | — | |
| SCHEMBL15956594 | 0.80 | LMNA (0.42) | LMNAMAP3K14HCAR2KDM4ENPC1 | |
| SCHEMBL1298778 | 0.74 | LMNA (0.38) | LMNAMAP3K14KDM4ENPC1RAB9A | |
| SCHEMBL2060019 | 0.74 | LMNA (0.38) | LMNAMAP3K14KDM4ETSHRCYP2C19 | |
| SCHEMBL15956851 | 0.71 | CYP2C9 (0.37) | LMNAMAP3K14KDM4ENPC1RAB9A | |
| SCHEMBL15527837 | 0.70 | GAA (0.44) | LMNAKDM4ENPC1RAB9ACYP2D6 | |
| SCHEMBL13088423 | 0.70 | LMNA (0.40) | LMNAMAP3K14KDM4ENPC1RAB9A | |
| SCHEMBL25262175 | 0.69 | LMNA (0.37) | LMNAMAP3K14KDM4ENPC1RAB9A | |
| SCHEMBL28339239 | 0.68 | PARP1 (0.37) | LMNAKDM4ENPC1RAB9ACYP2C19 | |
| SCHEMBL28339241 | 0.68 | PARP1 (0.37) | LMNAKDM4ENPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198438-B2 | Pyrrolotriazine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-06-12 | — | — | US | disclosed |
| US-20100113454-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-05-06 | — | — | US | disclosed |
| EP-2134716-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008131050-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113454-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | STK25, LCK, MAP3K15 | LMNA 4637/4885MAP3K14 40/4885HCAR2 2441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.