Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14957015 | 0.77 | KDM4E (0.47) | TGFBR1NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL14750950 | 0.75 | ADH5 (0.49) | TGFBR1MEN1MAPTKMT2AADH5 | |
| SCHEMBL2868846 | 0.73 | KDM4E (0.38) | TGFBR1NAPRTNPC1RAB9AALDH1A1 | |
| SCHEMBL496758 | 0.73 | NPC1 (0.60) | TGFBR1NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL27077073 | 0.71 | TGFBR1 (0.48) | TGFBR1TGFBR2ADORA2ACLK1EPHB3 | |
| SCHEMBL9753957 | 0.71 | KDM4E (0.50) | TGFBR1NAPRTNPC1RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL21834227 | 0.71 | NPC1 (0.59) | TGFBR1NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL2817471 | 0.70 | ADORA2A (0.54) | TGFBR1KDM4ETGFBR2ADORA2A | |
| SCHEMBL1649588 | 0.70 | TGFBR1 (0.47) | TGFBR1ALDH1A1KDM4ETGFBR2ADORA2A | |
| SCHEMBL14756587 | 0.70 | TGFBR1 (0.48) | TGFBR1TGFBR2ADORA2ACLK1EPHB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113531-A1 | THIAZOLIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-05-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113531-A1 | THIAZOLIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | HCRTR1, HCRTR2, NPY1R | TGFBR1 296/4885NAPRT 1347/4885NPC1 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.