Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3315802 | 0.72 | HTR2B (0.41) | LTB4RLTB4R2DRD2DRD3HTR2B | |
| SCHEMBL24915634 | 0.72 | LTB4R (0.45) | MAOALTB4RLTB4R2HTR2AP2RX7 | |
| SCHEMBL506553 | 0.72 | PDPK1 (0.46) | LTB4RLTB4R2HTR2ACYP2D6SLC6A2 | |
| SCHEMBL12649085 | 0.71 | DRD2 (0.45) | SSTR4CHRNB4CHRNA3LTB4RLTB4R2 | |
| Hydrochloric Acid SCHEMBL30799506 | 0.71 | PDPK1 (0.44) | HTR2ACYP2D6SLC6A2SLC6A4 | |
| SCHEMBL7847793 | 0.70 | DRD2 (0.48) | SSTR4CHRNB4CHRNA3LTB4RLTB4R2 | |
| SCHEMBL6245152 | 0.70 | DRD2 (0.48) | SSTR4CHRNB4CHRNA3LTB4RLTB4R2 | |
| SCHEMBL7846711 | 0.70 | DRD2 (0.48) | SSTR4CHRNB4CHRNA3LTB4RLTB4R2 | |
| SCHEMBL29960480 | 0.70 | DRD2 (0.48) | SSTR4CHRNB4CHRNA3LTB4RLTB4R2 | |
| SCHEMBL7846708 | 0.70 | DRD2 (0.48) | SSTR4CHRNB4CHRNA3LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105651-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R&D) LIMITED (GB) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105651-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | CNR1, OPRL1, CHRNA10 | SSTR4 639/4885CHRNB4 47/4885CHRNA3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.