Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.64 |
| ▸ | CDK2 | P24941 | 4/20 | 0.64 |
| ▸ | EGFR | P00533 | 10/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.51 |
| ▸ | INSR | P06213 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3313619 | 0.84 | IGF1R (0.71) | IGF1RCDK2EGFRKCNH2INSR | |
| SCHEMBL3352606 | 0.83 | IGF1R (0.79) | IGF1RCDK2EGFRKCNH2INSR | |
| SCHEMBL3313620 | 0.82 | IGF1R (0.84) | IGF1RCDK2EGFRKCNH2CYP3A4 | |
| SCHEMBL2349113 | 0.82 | IGF1R (0.70) | IGF1RCDK2EGFRKCNH2INSR | |
| SCHEMBL3311495 | 0.80 | IGF1R (0.64) | IGF1RCDK2EGFRKCNH2INSR | |
| SCHEMBL2351237 | 0.78 | IGF1R (1.00) | IGF1RCDK2EGFRKCNH2INSR | |
| SCHEMBL2348174 | 0.78 | IGF1R (0.77) | IGF1RCDK2EGFRKCNH2INSR | |
| SCHEMBL2347443 | 0.78 | IGF1R (0.69) | IGF1RCDK2EGFRKCNH2INSR | |
| SCHEMBL2362138 | 0.77 | IGF1R (0.64) | IGF1RCDK2EGFRKCNH2INSR | |
| SCHEMBL2345721 | 0.77 | IGF1R (0.85) | IGF1RCDK2EGFRKCNH2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | TYMS, ABCG2, UMPS | IGF1R 4384/4885CDK2 64/4885EGFR 2481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.