SCHEMBL33148

SCHEMBL33148

CNc1nc(NC)nc(OC)n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.52
MAPK1 P28482 2/20 0.52
PDE4A P27815 2/20 0.51
PDE7A Q13946 1/20 0.51
CYP1A2 P05177 2/20 0.47
CYP2C19 P33261 2/20 0.47
POLB P06746 1/20 0.41
ALDH1A1 P00352 3/20 0.39
LMNA P02545 3/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
TSHR P16473 1/20 0.39
GAA P10253 3/20 0.38
MAPT P10636 3/20 0.37
HTT P42858 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
CFTR P13569 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CA1 P00915 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL33144 0.94 MAPK1 (0.52) SMN1; SMN2MAPK1PDE4APDE7ACYP1A2
SCHEMBL2245306 0.85 GAA (0.55) SMN1; SMN2MAPK1PDE4APDE7ACYP1A2
SCHEMBL29462964 0.85 KMT2A (0.53) SMN1; SMN2MAPK1PDE4APDE7ACYP1A2
SCHEMBL2682570 0.85 KMT2A (0.53) SMN1; SMN2MAPK1PDE4APDE7ACYP1A2
SCHEMBL5913975 0.84 PDE4A (0.48) SMN1; SMN2MAPK1PDE4APDE7ACYP1A2
SCHEMBL11160381 0.84 POLB (0.51) SMN1; SMN2MAPK1PDE4APDE7ACYP1A2
SCHEMBL10922024 0.82 GAA (0.51) SMN1; SMN2MAPK1PDE4APDE7ACYP1A2
SCHEMBL9197498 0.80 MAPK1 (0.42) SMN1; SMN2MAPK1PDE4APDE7ACYP1A2
SCHEMBL9155654 0.80 MAPK1 (0.42) SMN1; SMN2MAPK1PDE4APDE7ACYP1A2
SCHEMBL25083760 0.79 PDE4A (0.49) SMN1; SMN2MAPK1PDE4APDE7APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2028212-B1 Cynate-based structure plastic filled with carbon dioxide and method for its production FRAUNHOFER GES FORSCHUNG (DE) 2011-11-16 EP disclosed
US-8026292-B2 Cyanate-based, carbon-dioxide-filled structured foams and method for their production Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2011-09-27 US disclosed
US-8026292-B2 Cyanate-based, carbon-dioxide-filled structured foams and method for their production Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2011-09-27 US disclosed
US-20090054540-A1 Cyanate-Based, Carbon-Dioxide-Filled Structured Foams and Method for Their Production FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) 2009-02-26 US disclosed
US-20090054540-A1 Cyanate-Based, Carbon-Dioxide-Filled Structured Foams and Method for Their Production FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) 2009-02-26 US disclosed
EP-2028212-A1 Cynate-based structure plastic filled with carbon dioxide and method for its production Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2009-02-25 EP disclosed
EP-2028212-A1 Cynate-based structure plastic filled with carbon dioxide and method for its production Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2009-02-25 EP disclosed