⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3314667 | 0.89 | BRD4 (0.36) | — | |
| SCHEMBL699953 | 0.75 | CPN1 (0.30) | — | |
| SCHEMBL6134736 | 0.70 | MAPK1 (0.34) | — | |
| SCHEMBL27793398 | 0.67 | ALDH1A1 (0.40) | — | |
| SCHEMBL28718157 | 0.66 | CYP2C9 (0.35) | — | |
| SCHEMBL21550954 | 0.66 | AKR1C3 (0.47) | — | |
| SCHEMBL2706677 | 0.65 | DPP8 (0.33) | — | |
| SCHEMBL12016032 | 0.65 | GNAI3 (0.45) | — | |
| SCHEMBL20395373 | 0.65 | MEN1 (0.39) | — | |
| SCHEMBL17373331 | 0.65 | MEN1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105916-A1 | Processes for Preparing Donepezil | Sterling Biotech Limited (IN) | 2010-04-29 | — | — | US | disclosed |
| EP-1531151-B1 | A process for the preparation of 1-benzyl-4-¬(5,6-dimethoxy-1-indanon)-2-yl| methyl piperidine hydrochloride (donepezil hcl) | USV LTD (IN) | 2007-03-07 | — | — | EP | disclosed |
| US-6953856-B2 | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) | USV, LIMITED (IN) | 2005-10-11 | — | — | US | disclosed |
| EP-1531151-A1 | A process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl] methyl piperidine hydrochloride (donepezil hcl) | USV Limited (IN) | 2005-05-18 | — | — | EP | disclosed |
| US-20040158070-A1 | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) | USV LIMITED, BSD MARG. (IN) | 2004-08-12 | — | — | US | disclosed |
| US-6649765-B1 | Hydrogenating 5,6-Dimethoxy-2-(pyridin-4-yl)methylene indan-1-one in the presence of catalysts, then alkylating with benzyl bromide, to form drugs used for prophylaxis of nervous system disorders; by product inhibition | USV LIMITED, BSD MARG. (IN) | 2003-11-18 | — | — | US | disclosed |