Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | TGM1 | P22735 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3315611 | 1.00 | HDAC1 (0.47) | HDAC1GPR119HSD11B1PARP1AR | |
| SCHEMBL31126227 | 0.90 | GPR119 (0.46) | HDAC1GPR119HSD11B1PARP1AR | |
| SCHEMBL27175311 | 0.88 | HDAC1 (0.45) | HDAC1GPR119HSD11B1PARP1AR | |
| SCHEMBL30833054 | 0.88 | HDAC1 (0.45) | HDAC1GPR119HSD11B1PARP1AR | |
| SCHEMBL24620612 | 0.88 | HDAC1 (0.45) | HDAC1GPR119HSD11B1PARP1AR | |
| SCHEMBL24620260 | 0.88 | HDAC1 (0.45) | HDAC1GPR119HSD11B1PARP1AR | |
| SCHEMBL30833056 | 0.88 | HDAC1 (0.45) | HDAC1GPR119HSD11B1PARP1AR | |
| SCHEMBL30412361 | 0.85 | HDAC1 (0.47) | HDAC1GPR119HSD11B1PARP1AR | |
| SCHEMBL30411723 | 0.85 | HDAC1 (0.47) | HDAC1GPR119HSD11B1PARP1AR | |
| SCHEMBL30412220 | 0.84 | HDAC1 (0.47) | HDAC1GPR119HSD11B1PARP1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | TYMS, ABCG2, UMPS | HDAC1 1720/4885GPR119 365/4885HSD11B1 1067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.