Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | GLA | P06280 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15004608 | 0.81 | KMT2A (0.61) | KDM4EALDH1A1GLAGAAHSD17B10 | |
| SCHEMBL30172989 | 0.79 | KDM4E (0.52) | KDM4EALDH1A1GLAGAAHSD17B10 | |
| SCHEMBL13050157 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1GLAGAAHSD17B10 | |
| SCHEMBL3861933 | 0.75 | ALDH1A1 (0.51) | KDM4EALDH1A1GLAGAAHSD17B10 | |
| SCHEMBL15764112 | 0.75 | ALDH1A1 (0.50) | KDM4EALDH1A1GLAGAAHSD17B10 | |
| SCHEMBL9517166 | 0.74 | ALDH1A1 (0.46) | KDM4EALDH1A1GLAGAAHSD17B10 | |
| SCHEMBL1816550 | 0.74 | KDM4E (0.68) | KDM4EALDH1A1GLAGAAHSD17B10 | |
| SCHEMBL13732765 | 0.72 | ALDH1A1 (0.66) | KDM4EALDH1A1GLAGAAHSD17B10 | |
| SCHEMBL9517202 | 0.72 | ALDH1A1 (0.44) | KDM4EALDH1A1GLAGAAHSD17B10 | |
| SCHEMBL29174927 | 0.72 | PTGS1 (0.61) | KDM4EALDH1A1GLAGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | TYMS, ABCG2, UMPS | KDM4E 2169/4885ALDH1A1 649/4885GLA 2996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.