Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3318194 | 0.84 | POLB (0.47) | HIF1ALMNACYP2C9MAPTPTGS1 | |
| SCHEMBL3316855 | 0.83 | NPBWR1 (0.40) | HIF1ALMNACYP2C9MCHR1NPBWR1 | |
| SCHEMBL3318294 | 0.80 | HIF1A (0.41) | HIF1AMCHR1NPBWR1MAPTPTGS2 | |
| SCHEMBL3318073 | 0.78 | NPBWR1 (0.43) | CYP2C9MCHR1NPBWR1MAPTSMN1; SMN2 | |
| SCHEMBL5732307 | 0.71 | MAPT (0.44) | HIF1ALMNACYP2C9MCHR1NPBWR1 | |
| SCHEMBL17910800 | 0.71 | MAPT (0.49) | HIF1ALMNACYP2C9MCHR1NPBWR1 | |
| SCHEMBL1491081 | 0.71 | POLB (0.58) | LMNACYP2C9NPBWR1MAPTPTGS1 | |
| SCHEMBL5732303 | 0.70 | NPBWR1 (0.43) | HIF1ALMNACYP2C9MCHR1NPBWR1 | |
| SCHEMBL3244643 | 0.69 | CYP2C9 (0.52) | HIF1ALMNACYP2C9MCHR1NPBWR1 | |
| SCHEMBL15553292 | 0.67 | MAPT (0.48) | HIF1ALMNACYP2C9MCHR1NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144812-A1 | Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production Containing an Azole | WYETH LLP (US) | 2010-06-10 | — | — | US | disclosed |
| US-7674813-B2 | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole | WYETH (US) | 2010-03-09 | — | — | US | disclosed |
| EP-1709003-B1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH CORP (US) | 2009-09-23 | — | — | EP | disclosed |
| US-20080249150-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2008-10-09 | — | — | US | disclosed |
| US-7399778-B2 | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole | WYETH (US) | 2008-07-15 | — | — | US | disclosed |
| EP-1709003-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | Wyeth (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073198-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2005-08-11 | — | — | WO | disclosed |
| US-20050171180-A1 | Heterocyclic sulfonamide inhibtors of beta amyloid production containing an azole | WYETH (US) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144812-A1 | Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production Containing an Azole | APP, IAPP, PARK7 | HIF1A 3064/4885LMNA 2937/4885CYP2C9 726/4885 |
| US-20080249150-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | APP, IAPP, PARK7 | HIF1A 3064/4885LMNA 2937/4885CYP2C9 726/4885 |
| US-20050171180-A1 | Heterocyclic sulfonamide inhibtors of beta amyloid production containing an azole | IAPP, APP, CBR3 | HIF1A 2753/4885LMNA 2624/4885CYP2C9 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.