Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.66 |
| ▸ | CCR2 | P41597 | 9/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3317115 | 1.00 | ROCK2 (0.66) | ROCK2ROCK1CCR2 | |
| SCHEMBL3316892 | 0.94 | ROCK2 (0.67) | ROCK2ROCK1CCR2 | |
| SCHEMBL3316899 | 0.94 | ROCK2 (0.67) | ROCK2ROCK1CCR2 | |
| SCHEMBL3312177 | 0.93 | ROCK2 (0.65) | ROCK2ROCK1CCR2 | |
| SCHEMBL3311962 | 0.93 | ROCK2 (0.57) | ROCK2ROCK1CCR2 | |
| SCHEMBL3311971 | 0.93 | ROCK2 (0.57) | ROCK2ROCK1CCR2 | |
| SCHEMBL3315406 | 0.92 | ROCK2 (0.61) | ROCK2ROCK1CCR2 | |
| SCHEMBL3315415 | 0.92 | ROCK2 (0.61) | ROCK2ROCK1CCR2 | |
| SCHEMBL3311382 | 0.91 | ROCK2 (0.53) | ROCK2ROCK1CCR2 | |
| SCHEMBL3313404 | 0.90 | ROCK2 (0.64) | ROCK2ROCK1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8748614-B2 | Substituted isoquinoline and isoquinolinone derivatives | SANOFI (FR) | 2014-06-10 | — | — | US | disclosed |
| US-20100105650-A1 | Substituted isoquinoline and isoquinolinone derivatives | SANOFI-AVENTIS (FR) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105650-A1 | Substituted isoquinoline and isoquinolinone derivatives | MYLK2, MYLK, MYLK3 | ROCK2 6/4885ROCK1 5/4885CCR2 3379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.