Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 5/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17376745 | 0.73 | CREBBP (0.42) | CREBBPBRPF1KMT2AMEN1GAA | |
| SCHEMBL13834469 | 0.71 | KMT2A (0.68) | KMT2AMEN1GAAMAPTNPC1 | |
| SCHEMBL12841651 | 0.69 | CREBBP (0.39) | CREBBPBRPF1KMT2AMEN1GAA | |
| SCHEMBL13949315 | 0.69 | MAPT (0.43) | CREBBPBRPF1KMT2AMEN1GAA | |
| SCHEMBL9718691 | 0.69 | CREBBP (0.39) | CREBBPBRPF1KMT2AMEN1GAA | |
| SCHEMBL8279432 | 0.69 | CREBBP (0.50) | CREBBPBRPF1KMT2AMEN1GAA | |
| SCHEMBL4265282 | 0.69 | CREBBP (0.39) | CREBBPBRPF1KMT2AMEN1GAA | |
| SCHEMBL6587899 | 0.69 | CREBBP (0.50) | CREBBPBRPF1KMT2AMEN1GAA | |
| SCHEMBL5458130 | 0.69 | IDO1 (0.46) | CREBBPBRPF1KMT2AMEN1GAA | |
| SCHEMBL30570964 | 0.69 | CREBBP (0.50) | CREBBPBRPF1KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858105-B2 | Inhibitors of melanocyte tyrosinase as topical skin lighteners | MEDIQUEST THERAPEUTICS, INC. (US) | 2010-12-28 | — | — | US | disclosed |
| EP-1857109-B1 | Inhibitors of melanocyte tyrosinase as topical skin lighteners | MEDIQUEST THERAPEUTICS INC (US) | 2010-09-22 | — | — | EP | disclosed |
| US-7718185-B2 | Inhibitors of melanocyte tyrosinase as topical skin lighteners | MEDIQUEST THERAPEUTICS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-20090023792-A1 | INHIBITORS OF MELANOCYTE TYROSINASE AS TOPICAL SKIN LIGHTENERS | MEDIQUEST THERAPEUTICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
| US-20090023793-A1 | INHIBITORS OF MELANOCYTE TYROSINASE AS TOPICAL SKIN LIGHTENERS | MEDIQUEST THERAPEUTICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
| EP-1857109-A2 | Inhibitors of melanocyte tyrosinase as tropical skin lighteners | MediQuest Therapeutics, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| EP-1267868-B1 | INHIBITORS OF MELANOCYTE TYROSINASE AS TOPICAL SKIN LIGHTENERS | MEDIQUEST THERAPEUTICS INC (US) | 2007-07-18 | — | — | EP | disclosed |
| US-20050152859-A1 | Inhibitors of melanocyte tyrosinase as topical skin lighteners | MEDIQUEST THERAPEUTICS, INC. (US) | 2005-07-14 | — | — | US | disclosed |
| US-20030219393-A1 | Inhibitors of melanocyte tyrosinase as topical skin lighteners | INTEGRIDERM, INC. | 2003-11-27 | — | — | US | disclosed |
| EP-1267868-A2 | INHIBITORS OF MELANOCYTE TYROSINASE AS TOPICAL SKIN LIGHTENERS | Integriderm, Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| US-20020044914-A1 | Inhibitors of melanocyte tyrosinase as topical skin lighteners | INTEGRIDERM, INC. | 2002-04-18 | — | — | US | disclosed |
| WO-2001064206-A2 | INHIBITORS OF MELANOCYTE TYROSINASE AS TOPICAL SKIN LIGHTENERS | INTEGRIDERM, INC. (US) | 2001-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050152859-A1 | Inhibitors of melanocyte tyrosinase as topical skin lighteners | TYR, MC1R, MITF | CREBBP 1269/4885BRPF1 3071/4885KMT2A 1086/4885 |
| US-20030219393-A1 | Inhibitors of melanocyte tyrosinase as topical skin lighteners | TYR, MC1R, MITF | CREBBP 1269/4885BRPF1 3071/4885KMT2A 1086/4885 |
| US-20090023792-A1 | INHIBITORS OF MELANOCYTE TYROSINASE AS TOPICAL SKIN LIGHTENERS | TYR, MC1R, MITF | CREBBP 1269/4885BRPF1 3071/4885KMT2A 1086/4885 |
| US-20020044914-A1 | Inhibitors of melanocyte tyrosinase as topical skin lighteners | TYR, MC1R, MITF | CREBBP 1269/4885BRPF1 3071/4885KMT2A 1086/4885 |
| US-20090023793-A1 | INHIBITORS OF MELANOCYTE TYROSINASE AS TOPICAL SKIN LIGHTENERS | TYR, MC1R, MITF | CREBBP 1269/4885BRPF1 3071/4885KMT2A 1086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.